Chilblain-like skin changes during COVID-19 infection
Official title: Assessment of Skin Manifestations Occuring During Covid-19 Infection With a Special Focus on Chilbains
Run by Centre Hospitalier Universitaire de Nice · NCT04344119 · Data updated 2026-11-12
This observational study looks at people with COVID-19 who develop skin lesions that look like chilblains to see what these sores have in common and what they might mean for the disease overall.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 90 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | April 9, 2020 |
| Main results expected | April 30, 2021 |
| Study ends | June 25, 2027 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT04344119 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a proven COVID-19 infection who develop at least one cutaneous lesion during the infection.
✕Probably not a fit
Patients without skin manifestations or without confirmed infection may not benefit from the study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study aims to characterize acral skin manifestations that appear during COVID-19, focusing on chilblain-like lesions. It plans to analyze clinical and dermoscopic patterns and relate them to non-invasive vascular tests, as well as immune and coagulation studies conducted at CHU de Nice. By comparing findings across patients with confirmed infection and skin involvement, the research seeks to clarify potential pathogenetic mechanisms, including viral effects, microthrombosis, or inflammatory vascular processes. The observational design leverages existing clinical evaluations to correlate skin features with systemic markers and imaging results. No interventions are specified, and results may inform understanding of cutaneous and related systemic manifestations of COVID-19.
Why it matters
Potential benefit: Gaining clearer insights into how COVID-19 affects the skin and blood vessels, which could improve recognition and understanding of disease processes.
How similar studies have gone: Previous observations have described chilblain-like lesions in COVID-19 and related studies have contributed to understanding skin involvement, though pathogenetic links remain under investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with proven covid infection (using PCR, serum antibody or lung TDM) and presenting at least one cutaneous lesions that occurred during the infection.
Where it's running
-
CHU de Nice
Nice, France Recruiting
Study contacts
- Study coordinator: Cynthia CAILLON
- Email: caillon.c@chu-nice.fr
- Phone: +33492034011
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.