Clinical trial Recruiting at 1 site Interventional

Cerebral oximetry-guided care after cardiac arrest

Official title: Cerebral Oximetry in Management of Post Cardiac Arrest (COMPACT): A Pilot Randomized Controlled Trial

Run by University of Calgary · NCT07829887 · Data updated 2026-11-12

This study tests whether using a brain oxygen monitor can help guide treatment for adults who have had a cardiac arrest to protect the brain and improve outcomes.

Quick facts

Study typeInterventional
SexAll
Enrollment44 (estimated)
SponsorUniversity of Calgary
Academic / other
Locations1 site (Calgary, Alberta)
StatusRecruiting
StartedOctober 10, 2025
Main results expectedFebruary 2027
Study endsMay 2027
Registry record updatedSeptember 21, 2026
Trial IDNCT07829887 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) who have had a cardiac arrest lasting at least five minutes and are comatose (GCS 8 or less) after resuscitation.

Probably not a fit

Patients with cardiac arrest due to diffuse brain injury, or those unable to enroll within six hours or with unsupportable physiology, may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores cerebral oximetry, a non-invasive device that measures brain oxygen levels, to guide treatment after cardiac arrest. Eligible adults who have experienced either in- or out-of-hospital cardiac arrest lasting at least five minutes and who are severely impaired on arrival to ICU are enrolled. The approach compares standard care with cerebral oximetry-guided management to see if maintaining brain oxygen delivery can reduce brain injury and improve recovery. The study is led by the University of Calgary and conducted at Foothills Medical Center in Calgary, Canada. No phase designation is provided for this trial.

Why it matters

Potential benefit: If successful, cerebral oximetry-guided care could help preserve brain function and improve neurological outcomes after cardiac arrest.

How similar studies have gone: Prior research suggests brain oxygen monitoring is promising, but the effectiveness of guiding treatment in this setting remains to be confirmed.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age \>= 18 years
* Cardiac arrest (in- or out-of-hospital) lasting \>= 5 minutes
* Glasgow Coma Scale score \<= 8 and motor score \<= 5

Exclusion Criteria:

* Cardiac arrest cause was any form of brain injury
* Cannot be enrolled within 6 hours
* Unsupportable physiology
* CT scan (not mandated) showing diffuse loss of grey-white differentiation

Where it's running

  • Foothills Medical Center
    Calgary, Alberta, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.