Cerebral oximetry-guided care after cardiac arrest
Official title: Cerebral Oximetry in Management of Post Cardiac Arrest (COMPACT): A Pilot Randomized Controlled Trial
Run by University of Calgary · NCT07829887 · Data updated 2026-11-12
This study tests whether using a brain oxygen monitor can help guide treatment for adults who have had a cardiac arrest to protect the brain and improve outcomes.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 44 (estimated) |
| Sponsor | University of Calgary Academic / other |
| Locations | 1 site (Calgary, Alberta) |
| Status | Recruiting |
| Started | October 10, 2025 |
| Main results expected | February 2027 |
| Study ends | May 2027 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT07829887 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who have had a cardiac arrest lasting at least five minutes and are comatose (GCS 8 or less) after resuscitation.
✕Probably not a fit
Patients with cardiac arrest due to diffuse brain injury, or those unable to enroll within six hours or with unsupportable physiology, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study explores cerebral oximetry, a non-invasive device that measures brain oxygen levels, to guide treatment after cardiac arrest. Eligible adults who have experienced either in- or out-of-hospital cardiac arrest lasting at least five minutes and who are severely impaired on arrival to ICU are enrolled. The approach compares standard care with cerebral oximetry-guided management to see if maintaining brain oxygen delivery can reduce brain injury and improve recovery. The study is led by the University of Calgary and conducted at Foothills Medical Center in Calgary, Canada. No phase designation is provided for this trial.
Why it matters
Potential benefit: If successful, cerebral oximetry-guided care could help preserve brain function and improve neurological outcomes after cardiac arrest.
How similar studies have gone: Prior research suggests brain oxygen monitoring is promising, but the effectiveness of guiding treatment in this setting remains to be confirmed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>= 18 years * Cardiac arrest (in- or out-of-hospital) lasting \>= 5 minutes * Glasgow Coma Scale score \<= 8 and motor score \<= 5 Exclusion Criteria: * Cardiac arrest cause was any form of brain injury * Cannot be enrolled within 6 hours * Unsupportable physiology * CT scan (not mandated) showing diffuse loss of grey-white differentiation
Where it's running
-
Foothills Medical Center
Calgary, Alberta, Canada Recruiting
Study contacts
- Study coordinator: Andreas H Kramer, MD MSc FRCPC
- Email: andreas.kramer@albertahealthservices.ca
- Phone: 403-944-4749
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.