Personalized PEEP strategy for intrinsic PEEP during one-lung ventilation
Official title: Effects of Individualized Positive End-expiratory Pressure (PEEP) on Intrinsic PEEP and Stroke Volume During One-lung Ventilation: a Single-center, Randomized Crossover Study
Run by Samsung Medical Center · NCT07638176 · Data updated 2026-11-12
The study tests three PEEP approaches (0, 5, and a personalized level based on intrinsic PEEP) to see which best supports patients with intrinsic PEEP during lung surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years to 100 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Samsung Medical Center Academic / other |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | May 31, 2027 |
| Study ends | May 31, 2027 |
| Registry record updated | September 14, 2026 |
| Trial ID | NCT07638176 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (ASA I-III) undergoing lung resection with one-lung ventilation for more than 60 minutes and who develop intrinsic PEEP during ventilation.
✕Probably not a fit
Patients without intrinsic PEEP during one-lung ventilation or those not meeting eligibility may not benefit from this strategy.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, crossover trial compares three extrinsic PEEP settings in patients with intrinsic PEEP during one-lung ventilation for lung resection. The goal is to see how different PEEP levels affect intrinsic PEEP dynamics and hemodynamic stability. Participants are adults with COPD or related pulmonary disease undergoing lung resection, and the intervention uses a double-lumen tube with standardized ventilation protocols. The study design allows each patient to experience all three PEEP strategies to directly compare effects within individuals. Outcomes focus on iPEEP changes and cardiovascular response during the operative period.
Why it matters
Potential benefit: If successful, the trial could identify a PEEP approach that better maintains hemodynamic stability and controls intrinsic PEEP during one-lung ventilation.
How similar studies have gone: Prior work in critically ill patients suggests 70% of intrinsic PEEP as a strategy, but its applicability in intraoperative OLV is not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists Physical Status I - III * The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2 * Lung resection surgery requiring one-lung ventilation for over 60 minutes * Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr) * Patient who is diagnosed with intrinsic PEEP during one-lung ventilation Exclusion Criteria: * Large bullae * Emergency surgery * Mechanical ventilation before surgery * Hemodynamic instability before surgery * Surgery requiring cardiopulmonary bypass * Pregnancy, breastfeeding patient * Patient's refusal to participate * No intrinsic PEEP during one-lung ventilation
Where it's running
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Samsung Medical Center
Seoul, South Korea Recruiting
Study contacts
- Principal investigator: Hyun Joo Ahn, MD, PhD — Samsung Medical Center
- Study coordinator: Hyun Joo Ahn, MD, PhD
- Email: hyunjooahn@skku.edu
- Phone: +82234100784
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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AirGo Respiratory Monitoring During Lung Resection
Patients undergoing lung resection will wear the AirGo device to continuously monitor breathing before and after surgery to see if it helps track ventilation alongside standard checks.
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Capillary vs arterial blood gas analysis in COPD or APE patients with respiratory distress
This study tests whether a capillary blood gas test can replace the arterial test in adults with COPD flare or cardiogenic pulmonary edema who need non-invasive ventilation.
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Oxygen or low-pressure CPAP applied to the non-ventilated lung during lung resection
It tests whether giving oxygen or low-pressure CPAP to the non-ventilated lung during scheduled lung resection can reduce inflammation and postoperative complications in adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.