Can muscle stiffness measures help diagnose sarcopenia in older adults
Official title: Multimodal Assessment of Sarcopenia Using Shear Wave Elastography, Dual-Energy X-ray Absorptiometry, Bioelectrical Impedance Analysis, and Physical Performance Measures
Run by Kaohsiung Veterans General Hospital. · NCT07915310 · Data updated 2026-11-12
This study tests whether muscle stiffness from shear wave elastography, together with DXA, bioelectrical impedance, and physical performance tests, can identify sarcopenia in people 65 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Kaohsiung Veterans General Hospital. Academic / other |
| Locations | 1 site (Kaohsiung City) |
| Status | Recruiting |
| Started | October 21, 2026 |
| Main results expected | December 2026 |
| Study ends | April 2027 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT07915310 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 65 years and older who can walk independently and provide informed consent.
✕Probably not a fit
Individuals who do not show distinct SWE differences related to sarcopenia or who cannot complete the assessment procedures may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares older adults with and without sarcopenia to see if SWE-derived muscle stiffness correlates with muscle mass, strength, and function. Participants undergo SWE of selected muscles, a DXA scan for appendicular muscle mass, a BIA body composition measurement, and strength and performance tests. The goal is to determine if an integrated SWE-based model can accurately identify sarcopenia compared with DXA-based diagnosis. The study is focused on a population 65 and older and does not involve an interventional treatment.
Why it matters
Potential benefit: If successful, SWE-based assessment could enhance noninvasive sarcopenia screening and help tailor interventions.
How similar studies have gone: Previous work has explored SWE and body composition tools, with ongoing research on combining imaging and functional measures for sarcopenia.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 65 years and older * Able to walk independently, with or without an assistive device * Able to understand study procedures and provide written informed consent * Able to perform related exam Exclusion Criteria: * Implanted electronic medical devices (e.g., cardiac pacemaker or defibrillator), which contraindicate BIA measurement * Metal implants or prostheses in the regions measured by DXA or ultrasound * History of fracture or surgery of the lower extremities within the past 6 months * Neuromuscular disease affecting skeletal muscle (e.g., stroke with residual limb weakness, Parkinson's disease, myopathy, or amyotrophic lateral sclerosis) * Skin lesions, wounds, or infection at the ultrasound measurement sites * Acute illness or hospitalization within the past 4 weeks * Cognitive impairment or psychiatric conditions that preclude completion of study assessments * Inability to complete muscle strength or physical performance tests
Where it's running
-
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan Recruiting
Study contacts
- Study coordinator: Ming Hsuan Huang, MD
- Email: min0711@vghks.gov.tw
- Phone: +886 073422121
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.