Effects of hormones on energy metabolism in egg cells
Official title: Investigation of the Combined Effects of Luteinizing Hormone and Follicle-Stimulating Hormone on Metabolic Regulation in Cumulus Cells
Run by Kaohsiung Veterans General Hospital. · NCT06803199 · Data updated 2026-11-12
This study is testing if a combination of two hormones can improve energy use in egg cells for women aged 35-40 who are having trouble getting pregnant through IVF.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 35 Years to 40 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Kaohsiung Veterans General Hospital. Academic / other |
| Locations | 1 site (Kaohsiung City) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | January 31, 2025 |
| Trial ID | NCT06803199 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 35-40 with a BMI between 18-30 who are planning to undergo IVF cycles.
✕Probably not a fit
Patients with primary ovarian insufficiency, history of oophorectomy, or those receiving oocyte donation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how the combined treatment of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) affects energy metabolism in cumulus cells of infertile women aged 35-40 undergoing in vitro fertilization (IVF). Sixty participants will be divided into two groups, one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will analyze various patient characteristics, infertility history, and mitochondrial function in cumulus cells to evaluate the effectiveness of the treatments. The goal is to understand the mechanisms behind improved IVF pregnancy rates associated with combined hormone therapy.
Why it matters
Potential benefit: If successful, this study could enhance IVF outcomes for older infertile women by optimizing hormonal treatment protocols.
How similar studies have gone: Previous studies have shown improved IVF outcomes with combined FSH and LH therapy, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 35-40 years * BMI 18-30 kg/m2 * planning to undergo IVF cycles Exclusion Criteria: * Primary ovarian insufficiency * history of oophorectomy * receiving oocyte donation * Chromosome anomaly * Congenital uterine anomaly * Severe intrauterine adhesion * Malignancy * Using hormone therapy or supplements in recent 3 months
Where it's running
-
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan Recruiting
Study contacts
- Study coordinator: Li-Te Lin
- Email: litelin1982@gmail.com
- Phone: +88673464027
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating a potential treatment for ROSAH Syndrome using blood samples
This study is testing whether a new treatment can help reduce inflammation in blood cells from people with ROSAH Syndrome who have a specific genetic mutation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.