Effects of hormones on energy metabolism in egg cells
Investigation of the Combined Effects of Luteinizing Hormone and Follicle-Stimulating Hormone on Metabolic Regulation in Cumulus Cells
This study is testing if a combination of two hormones can improve energy use in egg cells for women aged 35-40 who are having trouble getting pregnant through IVF.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 35 Years to 40 Years |
| Sex | Female |
| Sponsor | Kaohsiung Veterans General Hospital. Academic / other |
| Locations | 1 site (Kaohsiung City) |
| Trial ID | NCT06803199 on ClinicalTrials.gov |
What this trial studies
This study investigates how the combined treatment of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) affects energy metabolism in cumulus cells of infertile women aged 35-40 undergoing in vitro fertilization (IVF). Sixty participants will be divided into two groups, one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will analyze various patient characteristics, infertility history, and mitochondrial function in cumulus cells to evaluate the effectiveness of the treatments. The goal is to understand the mechanisms behind improved IVF pregnancy rates associated with combined hormone therapy.
Who should consider this trial
Good fit: Ideal candidates are women aged 35-40 with a BMI between 18-30 who are planning to undergo IVF cycles.
Not a fit: Patients with primary ovarian insufficiency, history of oophorectomy, or those receiving oocyte donation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance IVF outcomes for older infertile women by optimizing hormonal treatment protocols.
How similar studies have performed: Previous studies have shown improved IVF outcomes with combined FSH and LH therapy, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 35-40 years * BMI 18-30 kg/m2 * planning to undergo IVF cycles Exclusion Criteria: * Primary ovarian insufficiency * history of oophorectomy * receiving oocyte donation * Chromosome anomaly * Congenital uterine anomaly * Severe intrauterine adhesion * Malignancy * Using hormone therapy or supplements in recent 3 months
Where this trial is running
Kaohsiung City
- Kaohsiung Veterans General Hospital — Kaohsiung City, Taiwan (Recruiting)
Study contacts
- Study coordinator: Li-Te Lin
- Email: litelin1982@gmail.com
- Phone: +88673464027
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.