Alpha-lipoic acid supplementation to see if IVF outcomes improve in older women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls 60 women aged 35-45 undergoing IVF and randomizes them to receive 600 mg/day of alpha-lipoic acid for two months prior to IVF or proceed to IVF without supplementation. The trial will compare oocyte and embryo quality, cumulus cell mitochondrial function, metabolic gene expression, and clinical outcomes such as pregnancy and live birth rates between groups. The investigation focuses on restoring mitochondrial function and reducing oxidative stress in the oocytes of older women to potentially enhance IVF success. The study is conducted at Kaohsiung Veterans General Hospital with 30 participants per arm.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 35-45 years
* BMI 18-35 kg/m²
* Planning to undergo IVF treatment using own oocytes

Exclusion Criteria:

* Primary ovarian insufficiency
* Azoospermia or severe male-factor infertility in the partner
* Congenital uterine anomaly
* Severe intrauterine adhesion
* Known chromosomal anomaly in either partner
* Malignancy
* Recipient of donor oocytes
* Known hypersensitivity/allergy to alpha-lipoic acid

Where it's running

• Kaohsiung Veterans General Hospital
  Kaohsiung City, Taiwan Recruiting

Study contacts

• Study coordinator: Li-Te Lin
• Email: litelin1982@gmail.com
• Phone: +886-7-3464027

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.