Calcium Gluconate-Activated PRP vs. Non-Activated PRP for ADD with Reduction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with ADDWR will be randomized to receive either calcium gluconate-activated PRP or non-activated PRP injected retrodiscaly. The study aims to see if the activated preparation yields better symptom relief and functional recovery, measured by changes in pain scores and the normal maximum mouth opening range. Outcomes will reflect changes over a defined follow-up period, with MRI-confirmed ADDWR diagnosis guiding inclusion. The insertion site targets the retrodiscal area to address disc instability without surgery. The trial will help determine if a chemically enhanced biologic treatment offers a meaningful clinical advantage.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-65 years.
* Clinical and MRI diagnosis of ADDWR per DCTMD criteria.
* Baseline VAS pain score 4-10.
* Failure of at least 2 conservative treatments (splint therapy, physiotherapy, NSAIDs) for 3 months.
* Written informed consent.

Exclusion Criteria:

* • Systemic inflammatory arthritis (Rheumatoid arthritis, etc.).

  * Recent TMJ surgery or intra-articular injection within the last 6 months.
  * Pregnancy or lactation.
  * Active TMJ infection or malignancy.
  * Coagulopathy or anticoagulant therapy.
  * Contraindications to MRI (e.g., pacemaker).

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Mohamed A. Osama, BDS
• Email: mohamed.madkour@dentistry.cu.edu.eg
• Phone: 01013127607

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.