Comparing high and low molecular weight hyaluronic acid for treating TMJ disorders
Official title: Comparative Study Between the Effectiveness of High Versus Low Molecular Weight Hyaluronic Acid in TMJ Arthrocentesis
Run by Assiut University · NCT06694532 · Data updated 2026-11-12
This study is testing whether high or low molecular weight hyaluronic acid injections can help people aged 17 to 70 with TMJ disorders feel better when other treatments haven't worked.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | October 31, 2023 |
| Main results expected | February 1, 2026 |
| Study ends | February 28, 2026 |
| Registry record updated | November 19, 2024 |
| Trial ID | NCT06694532 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 17 to 70 with painful TMJ symptoms and no improvement after conservative treatment.
✕Probably not a fit
Patients with muscular TMJ disorders or a bleeding tendency may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of high molecular weight versus low molecular weight hyaluronic acid injections in patients aged 17 to 70 with temporomandibular joint (TMJ) disorders who have not improved with conservative treatments. Participants will be divided into two groups, receiving different types of hyaluronic acid after undergoing arthrocentesis. The study will measure pain levels, mouth opening range, and the presence of joint noise to determine which treatment is more effective in alleviating symptoms.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients suffering from TMJ disorders.
How similar studies have gone: Previous studies have shown varying success with hyaluronic acid treatments for TMJ disorders, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pain or tenderness of the jaw * Pain in one or both of the temporomandibular joints * Aching pain in and around your ear * Difficulty chewing or pain while chewing * Aching facial pain * Locking of the joint, Exclusion Criteria: * Muscular TMJ disorders * Bleeding tendency
Where it's running
-
Assiut Univeristy
Asyut, Egypt Recruiting
Study contacts
- Principal investigator: Basel K Mohamed — Assiut Univeristy
- Study coordinator: Basel K Mohamed
- Email: Basel_shrider@yahoo.com
- Phone: +201099848089
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.