Clinical trial Recruiting at 1 site Phase1; Phase2 Interventional Ages 18 to 100

Comparing high and low molecular weight hyaluronic acid for treating TMJ disorders

Official title: Comparative Study Between the Effectiveness of High Versus Low Molecular Weight Hyaluronic Acid in TMJ Arthrocentesis

Run by Assiut University · NCT06694532 · Data updated 2026-11-12

This study is testing whether high or low molecular weight hyaluronic acid injections can help people aged 17 to 70 with TMJ disorders feel better when other treatments haven't worked.

More Temporomandibular Joint Disorders trials

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages18 Years to 100 Years
SexAll
Enrollment30 (estimated)
SponsorAssiut University
Academic / other
Locations1 site (Asyut)
StatusRecruiting
StartedOctober 31, 2023
Main results expectedFebruary 1, 2026
Study endsFebruary 28, 2026
Registry record updatedNovember 19, 2024
Trial IDNCT06694532 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 17 to 70 with painful TMJ symptoms and no improvement after conservative treatment.

Probably not a fit

Patients with muscular TMJ disorders or a bleeding tendency may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of high molecular weight versus low molecular weight hyaluronic acid injections in patients aged 17 to 70 with temporomandibular joint (TMJ) disorders who have not improved with conservative treatments. Participants will be divided into two groups, receiving different types of hyaluronic acid after undergoing arthrocentesis. The study will measure pain levels, mouth opening range, and the presence of joint noise to determine which treatment is more effective in alleviating symptoms.

Why it matters

Potential benefit: If successful, this study could provide a more effective treatment option for patients suffering from TMJ disorders.

How similar studies have gone: Previous studies have shown varying success with hyaluronic acid treatments for TMJ disorders, but this specific comparison is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pain or tenderness of the jaw
* Pain in one or both of the temporomandibular joints
* Aching pain in and around your ear
* Difficulty chewing or pain while chewing
* Aching facial pain
* Locking of the joint,

Exclusion Criteria:

* Muscular TMJ disorders
* Bleeding tendency

Where it's running

  • Assiut Univeristy
    Asyut, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.