Comparing high and low molecular weight hyaluronic acid for treating TMJ disorders
Comparative Study Between the Effectiveness of High Versus Low Molecular Weight Hyaluronic Acid in TMJ Arthrocentesis
This study is testing whether high or low molecular weight hyaluronic acid injections can help people aged 17 to 70 with TMJ disorders feel better when other treatments haven't worked.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Trial ID | NCT06694532 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of high molecular weight versus low molecular weight hyaluronic acid injections in patients aged 17 to 70 with temporomandibular joint (TMJ) disorders who have not improved with conservative treatments. Participants will be divided into two groups, receiving different types of hyaluronic acid after undergoing arthrocentesis. The study will measure pain levels, mouth opening range, and the presence of joint noise to determine which treatment is more effective in alleviating symptoms.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 17 to 70 with painful TMJ symptoms and no improvement after conservative treatment.
Not a fit: Patients with muscular TMJ disorders or a bleeding tendency may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients suffering from TMJ disorders.
How similar studies have performed: Previous studies have shown varying success with hyaluronic acid treatments for TMJ disorders, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pain or tenderness of the jaw * Pain in one or both of the temporomandibular joints * Aching pain in and around your ear * Difficulty chewing or pain while chewing * Aching facial pain * Locking of the joint, Exclusion Criteria: * Muscular TMJ disorders * Bleeding tendency
Where this trial is running
Asyut
- Assiut Univeristy — Asyut, Egypt (Recruiting)
Study contacts
- Principal investigator: Basel K Mohamed — Assiut Univeristy
- Study coordinator: Basel K Mohamed
- Email: Basel_shrider@yahoo.com
- Phone: +201099848089
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.