Breathing carbon dioxide to help with low blood pressure when standing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of inhaling carbon dioxide on patients with Neurogenic Orthostatic Hypotension (NOH) and healthy controls. The research focuses on how increased levels of carbon dioxide can stimulate the autonomic nervous system to improve blood pressure and alleviate symptoms associated with standing. Participants will undergo sequential gas delivery to assess changes in blood pressure and symptoms during postural transitions. The study also aims to explore potential sex differences in response to this intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Male and Female
* Non - smokers.
* Able and willing to provide informed consent.
* Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.

Exclusion Criteria:

* Medical therapies or medications which could interfere with testing of autonomic function
* Participants with somatization or severe anxiety symptoms will be excluded
* Pregnant or breast-feeding females
* Inability to tolerate mask for the duration of the study
* Subjects who require portable oxygen at rest or with exercise
* Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
* Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These include: dementia, alcohol and/or drug abuse, cerebrovascular disease, kidney or liver disease, surgical procedures where the nerves of the sympathetic nervous system have been cut.
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.

Where it's running

• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Satish R Raj, MD — University of Calgary
• Study coordinator: Jacquie Baker, PhD
• Email: jacquie.baker@ucalgary.ca
• Phone: 4032103819

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Breathing retraining for pregnant women with POTS

  This trial will test whether diaphragmatic breathing exercises help pregnant women with POTS reduce dizziness, rapid heart rate, and other orthostatic symptoms.

  Recruiting Riphah International University · Sialkot, Punjab Province · NCT07579026

• Fainting Detection and Early Warning Using a Wearable Monitor

  This study tests whether signals from a wearable Holter monitor can reflect the severity of orthostatic intolerance in people with fainting disorders.

  Recruiting Boston Scientific Corporation · Rochester, Minnesota · NCT07502599

• How blood pressure and heart rate respond to standing and exercise in healthy people and those with high blood pressure

  See if blood pressure, heart rate, and arterial stiffness during standing and graded bike exercise differ between healthy young adults and older adults with controlled high blood pressure, including those with orthostatic problems or diabetes.

  Recruiting University Medical Centre Ljubljana · Ljubljana · NCT07482462

• Polish registry of heart nerve–targeting treatments (cardioneuroablation and cardioneuromodulation)

  This registry collects information to see how nerve-targeting heart procedures work for adults with fainting, abnormal heart rhythms, or orthostatic problems.

  Recruiting SABAMED Medical Center Ltd. · Rzeszów · NCT07196397

• Using blood pressure and oxygen measurements to predict fall risk in older adults

  This study is trying to see if measuring blood pressure and oxygen levels can help predict fall risks in older adults who have fallen in the past year.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06714565

• Using a CO2 rebreather to improve blood pressure in patients with neurogenic orthostatic hypotension

  This study is testing whether a CO2 rebreather can help people with neurogenic orthostatic hypotension improve their blood pressure and feel better when standing up.

  Recruiting University of Calgary · Calgary, Alberta · NCT05908760

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.