Arterial stiffness in children and young people with CKD and hypertension
Official title: Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease
Run by King's College London · NCT07768865 · Data updated 2026-11-12
This study will test whether arterial stiffness is higher in children and young people with chronic kidney disease and high blood pressure compared with their peers, using a one-time assessment and follow-up for those with high BP.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 10 Years to 25 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | King's College London Academic / other |
| Locations | 1 site (London, Greater London) |
| Status | Recruiting |
| Started | June 16, 2026 |
| Main results expected | June 16, 2028 |
| Study ends | June 16, 2028 |
| Registry record updated | August 17, 2026 |
| Trial ID | NCT07768865 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children and young people aged 10–25 with CKD (including those on dialysis or with a kidney transplant) and matched peers without CKD.
✕Probably not a fit
Patients with CKD who do not show increased arterial stiffness or those who do not have elevated BP may not experience direct benefits from participation beyond study assessments.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares arterial stiffness in 10–25-year-olds with chronic kidney disease to age-, sex-, and BP-matched controls. It uses a single comprehensive assessment, including 24-hour blood pressure monitoring, blood/urine tests, arterial tonometry, MRI, echocardiography, and body measurements. A subset of CKD participants with elevated BP may have a second follow-up timepoint. The goal is to understand how CKD and hypertension relate to vascular aging in youth and identify potential risk factors for cardiovascular disease in this population.
Why it matters
Potential benefit: If successful, the study could clarify how CKD and high blood pressure contribute to arterial stiffness in youth, informing risk stratification and future interventions.
How similar studies have gone: Prior work suggests arterial stiffness is higher in youth with CKD and hypertension, supporting the rationale for this study, though the specific combination in this age group is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: For CKD participants: * Aged 10-25 years at study entry. * Diagnosis of CKD confirmed on at least two GFR assessments 3-months apart; eGFR will be estimated using routine bedside formulae (modified Schwartz). Participants may include those on dialysis or those with a functioning kidney transplant. * Able to tolerate study investigations including 24-hour ABPM, echocardiogram, vascular assessments and MRI. For controls: * Aged 10-25 years at study entry * Having completed study measurements as part of other research being completed by the research group and having consented to their anonymised data being used in future research within the same research theme. Exclusion criteria (for all participants): * Heart abnormalities or pre-existing cardiac disease including congenital heart disease, previous cardiac surgery or heart failure. * Cardiac dysrhythmia. * Inability to tolerate the required study investigations (out of office BP monitoring, applanation tonometry, cardiac MRI).
Where it's running
-
Evelina London Children's Hospital and Guys and St Thomas' NHS Foundation Trust
London, Greater London, United Kingdom Recruiting
Study contacts
- Principal investigator: Manish Sinha, PhD, MBBS — King's College London
- Study coordinator: Benjamin Boxer, BSc, PhD
- Email: benjamin.boxer@kcl.ac.uk
- Phone: +44 20 7188 4770
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.