Analyzing muscle parameters in patients with liver cirrhosis
Role of Skeletal Muscle Parameters in Imaging Analysis in the Prediction of Outcome in Patients With Liver Cirrhosis
This study is testing how different ways of measuring muscle health can help understand the outcomes for patients with liver cirrhosis who have had a specific procedure called TIPS.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University Hospital, Bonn Academic / other |
| Locations | 3 sites (Bonn and 2 other locations) |
| Trial ID | NCT03584204 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the skeletal muscle index (L3-SMI) in patients suffering from decompensated liver cirrhosis who have undergone transjugular intrahepatic portosystemic shunt (TIPS). It will compare the prognostic value of L3-SMI with transverse psoas muscle thickness (TPMT) and investigate the role of myosteatosis using various imaging techniques such as CT, MRI, and ultrasound. The study is observational and focuses on non-invasive imaging methods to assess muscle parameters and their implications for patient outcomes.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with liver cirrhosis of any etiology who have an available CT scan.
Not a fit: Patients with hepatocellular carcinoma (HCC) or any other malignant disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the prognostic assessment and management of patients with liver cirrhosis.
How similar studies have performed: Other studies have shown promising results in using imaging techniques to assess muscle parameters in liver disease, indicating that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * liver cirrhosis of any etiology * CT scan available Exclusion Criteria: * HCC or any malignant disease
Where this trial is running
Bonn and 2 other locations
- University Hospital Bonn — Bonn, Germany (Recruiting)
- University of Frankfurt — Frankfurt, Germany (Recruiting)
- Sapienza University of Rome — Roma, Italy (Recruiting)
Study contacts
- Principal investigator: Michael Praktiknjo, MD — University Hospital, Bonn
- Study coordinator: Michael Praktiknjo, MD
- Email: michael.praktiknjo@ukbonn.de
- Phone: +49228 287 15770
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.