Aldosterone-hybrid test to guide curable treatment for primary aldosteronism
Official title: Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA)
Run by Changi General Hospital · NCT07297745 · Data updated 2026-11-12
This trial tests whether non-invasive biomarkers plus CT imaging can identify unilateral primary aldosteronism and reduce the need for adrenal vein sampling in patients considered for surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Changi General Hospital Academic / other |
| Locations | 6 sites (Singapore, Singapore and 5 other locations) |
| Status | Recruiting |
| Started | January 15, 2026 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07297745 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with confirmed primary aldosteronism who are candidates for subtype testing and potential unilateral disease treated with surgery.
✕Probably not a fit
Patients without unilateral disease or without detectable biomarker signals may not benefit from the non-invasive approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study evaluates non-invasive biomarkers derived from hybrid hormones, in combination with routine CT imaging, to identify unilateral aldosterone-producing adenomas in primary aldosteronism. By potentially reducing reliance on invasive adrenal vein sampling, the trial aims to shorten diagnostic timelines and improve access to definitive, curative surgery. Eligible participants have confirmed primary aldosteronism and are considering subtype testing and possible surgical treatment. The study may use molecular imaging and adrenal vein sampling as part of the diagnostic pathway to validate non-invasive approaches. The goal is to create a safer, faster diagnostic pathway that can be applied globally.
Why it matters
Potential benefit: If successful, patients may experience faster, less invasive diagnosis and earlier access to curative surgery.
How similar studies have gone: Prior work shows that imaging and biomarkers can aid subtyping, but this specific non-invasive biomarker approach paired with CT is being tested for broader applicability.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed diagnosis of primary aldosteronism according to the Endocrine Society guideline 2025. * Willing to undergo subtype testing with adrenal vein sampling and/or molecular imaging (Positron Emission Tomography/Computed Tomography, PET/CT). * Keen for surgical treatment if shown to have unilateral primary aldosteronism. Exclusion Criteria: * Inability to provide written informed consent.
Where it's running
-
Changi General Hospital
Singapore, Singapore, Singapore Recruiting -
National University Hospital
Singapore, Singapore Recruiting -
Sengkang General Hospital
Singapore, Singapore Recruiting -
Singapore General Hospital
Singapore, Singapore Recruiting -
Khoo Teck Puat Hospital
Singapore, Singapore Not yet recruiting -
Tan Tock Seng Hospital
Singapore, Singapore Not yet recruiting
Study contacts
- Principal investigator: Troy Puar, FRCP, PhD — Changi General Hospital
- Study coordinator: Troy H Puar, FRCP, PhD
- Email: troy_puar@cgh.com.sg
- Phone: 67888833
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.