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Adrenal vein sampling in China

China Adrenal Venous Sampling Investigation: A National Multicenter Study

Observational Chinese Academy of Medical Sciences, Fuwai Hospital · NCT07252284

This project tests whether different adrenal venous sampling techniques and AVS-guided management help people with primary aldosteronism get better long-term blood pressure and hormone results.

Quick facts

Study typeObservational
Enrollment5000 (estimated)
Ages18 Years and up
SexAll
SponsorChinese Academy of Medical Sciences, Fuwai Hospital Academic / other
Locations76 sites (Hefei, Anhui and 75 other locations)
Trial IDNCT07252284 on ClinicalTrials.gov

What this trial studies

This is a multicenter observational study enrolling patients with confirmed primary aldosteronism who undergo adrenal venous sampling (AVS). The study will collect detailed clinical, technical, and methodological data on AVS procedures (including access approaches) and treatment decisions made after AVS. Patients will be followed over time for clinical and biochemical outcomes, medication use, and adverse cardiovascular events to link AVS findings with long-term prognosis. The protocol aims to standardize AVS practice and refine procedural methods across participating Chinese centers.

Who should consider this trial

Good fit: Adults with confirmed primary aldosteronism who are scheduled to undergo adrenal venous sampling for subtype classification and who meet standard safety criteria are ideal candidates.

Not a fit: Patients with recent severe comorbid events, significant renal impairment (eGFR <45 ml/min/1.73 m2), contrast allergy, suspected adrenocortical carcinoma, pregnancy, or those who refuse adrenalectomy are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, the findings could help clinicians choose optimal AVS methods and make better treatment decisions that improve blood pressure control, biochemical cure rates, and long-term cardiovascular outcomes for patients with primary aldosteronism.

How similar studies have performed: Adrenal venous sampling is an established gold-standard technique and prior studies have shown benefit from AVS-guided adrenalectomy, but large standardized multicenter evaluations—especially comparing different access techniques—remain limited.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Patients with confirmed primary aldosteronism;
2. Patients undergoing adrenal venous sampling for subtype classification of primary aldosteronism.

Exclusion Criteria:

1. Severe comorbidity, including stroke, myocardial infarction, heart failure, severe valvular heart disease, liver cirrhosis, and metastatic tumor within the previous 3 months；
2. An estimated glomerular filtration rate \<45 ml/min/1.73 m2, or serum creatinine \>176 μmol/L；
3. Patients who refuse adrenalectomy;
4. Suspected of having an adrenocortical carcinoma;
5. Allergy to contrast agent;
6. Pregnant, nursing, or planning to become pregnant

Where this trial is running

Hefei, Anhui and 75 other locations

+26 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions HyperaldosteronismAdrenal Venous SamplingAdrenalectomyAdrenal venous samplingAntecubital approachFemoral approachMain adverse cardiovascular events
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.