Rapid guideline-based therapy after a heart attack
Official title: Cardiovascular-kidney-metabolic (CKM)-Guided Therapy for Patients After Acute Coronary Syndrome
Run by Zuyderland Medisch Centrum · NCT07773272 · Data updated 2026-11-12
This project tests whether starting guideline-driven secondary prevention soon after a heart attack helps people who had PCI reach better risk-factor control and fewer heart events.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1215 (estimated) |
| Sponsor | Zuyderland Medisch Centrum Academic / other |
| Locations | 1 site (Heerlen, Limburg) |
| Status | Recruiting |
| Started | March 16, 2026 |
| Main results expected | March 31, 2029 |
| Study ends | March 31, 2029 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07773272 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 who were hospitalized with acute coronary syndrome and underwent PCI are eligible.
✕Probably not a fit
Patients with acute coronary syndrome due to another underlying disease or with less than 1 year life expectancy may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study follows adults who have had acute coronary syndrome and PCI to see if delivering rapid, guideline-based care for diabetes, blood pressure, and cholesterol improves outcomes compared with standard care over 24 months. The approach aligns with ESC recommendations and focuses on timely initiation of secondary prevention strategies. Primary outcomes include major adverse cardiac and cerebrovascular events within two years. The study compares patients treated according to the protocol to those receiving usual care in real-world settings. The lead site is Zuyderland Medisch Centrum in Heerlen, Netherlands.
Why it matters
Potential benefit: If successful, patients may achieve better control of diabetes, blood pressure, and cholesterol, reducing future heart-related events.
How similar studies have gone: Previous work in guideline-based secondary prevention suggests potential benefit, though this exact rapid-implementation approach is being explored in this observational framework.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Hospitalised with acute coronary syndrome * Underwent percutaneous coronary intervention Exclusion Criteria: * Acute coronary syndrome secondary to other diseases * Life expectancy \< 1 year based on the clinician's expertise
Where it's running
-
Cardiology
Heerlen, Limburg, Netherlands Recruiting
Study contacts
- Principal investigator: Saman Rasoul, MD, PhD — Zuyderland
- Study coordinator: Stan Toonen, MSc
- Email: s.toonen@zuyderland.nl
- Phone: +318854597522
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.