Clinical trial Recruiting at 1 site Observational Ages 18 and up

Rapid guideline-based therapy after a heart attack

Official title: Cardiovascular-kidney-metabolic (CKM)-Guided Therapy for Patients After Acute Coronary Syndrome

Run by Zuyderland Medisch Centrum · NCT07773272 · Data updated 2026-11-12

This project tests whether starting guideline-driven secondary prevention soon after a heart attack helps people who had PCI reach better risk-factor control and fewer heart events.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1215 (estimated)
SponsorZuyderland Medisch Centrum
Academic / other
Locations1 site (Heerlen, Limburg)
StatusRecruiting
StartedMarch 16, 2026
Main results expectedMarch 31, 2029
Study endsMarch 31, 2029
Registry record updatedAugust 19, 2026
Trial IDNCT07773272 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults over 18 who were hospitalized with acute coronary syndrome and underwent PCI are eligible.

Probably not a fit

Patients with acute coronary syndrome due to another underlying disease or with less than 1 year life expectancy may not benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows adults who have had acute coronary syndrome and PCI to see if delivering rapid, guideline-based care for diabetes, blood pressure, and cholesterol improves outcomes compared with standard care over 24 months. The approach aligns with ESC recommendations and focuses on timely initiation of secondary prevention strategies. Primary outcomes include major adverse cardiac and cerebrovascular events within two years. The study compares patients treated according to the protocol to those receiving usual care in real-world settings. The lead site is Zuyderland Medisch Centrum in Heerlen, Netherlands.

Why it matters

Potential benefit: If successful, patients may achieve better control of diabetes, blood pressure, and cholesterol, reducing future heart-related events.

How similar studies have gone: Previous work in guideline-based secondary prevention suggests potential benefit, though this exact rapid-implementation approach is being explored in this observational framework.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age \> 18 years
* Hospitalised with acute coronary syndrome
* Underwent percutaneous coronary intervention

Exclusion Criteria:

* Acute coronary syndrome secondary to other diseases
* Life expectancy \< 1 year based on the clinician's expertise

Where it's running

  • Cardiology
    Heerlen, Limburg, Netherlands
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.