Adding a distolingual injection to standard nerve blocks for lower wisdom tooth removal
Official title: Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar
Run by Watim Medical & Dental College · NCT07296926 · Data updated 2026-11-12
This will test whether adding a distolingual injection to the usual inferior alveolar and buccal nerve blocks reduces pain during lower wisdom tooth extraction in healthy adults aged 18–45.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Watim Medical & Dental College Academic / other |
| Locations | 1 site (Islamabad) |
| Status | Recruiting |
| Started | August 15, 2024 |
| Main results expected | February 15, 2026 |
| Study ends | April 15, 2026 |
| Registry record updated | January 6, 2026 |
| Trial ID | NCT07296926 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are otherwise healthy adults (18–45 years) with an impacted mandibular third molar requiring extraction who are ASA I–II, not allergic to lignocaine, and able to attend the Islamabad clinic.
✕Probably not a fit
Patients who are medically compromised (ASA III+), allergic to lignocaine, have contraindications to adrenaline, or require multiple extractions in one appointment are unlikely to qualify or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will enroll 120 patients requiring mandibular third molar extraction and randomize them to conventional inferior alveolar and buccal nerve blocks alone or the same blocks plus an additional distolingual infiltration. Pain during mucoperiosteal flap elevation and bone guttering will be recorded on a 0–10 Visual Analogue Scale. The primary comparison is intraoperative pain scores between the two groups to see if the extra infiltration improves anesthesia of the distolingual gingiva. Key exclusions include ASA III or higher, allergy to lignocaine, contraindication to adrenaline, and patients requiring multiple extractions in the same appointment.
Why it matters
Potential benefit: If successful, adding a distolingual infiltration could provide more complete numbness of the distolingual gingiva, reducing intraoperative pain and the need for rescue injections.
How similar studies have gone: Previous clinical reports and small series suggest supplemental distolingual infiltration can improve anesthesia for the distolingual gingiva, but randomized controlled data are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy individuals * Male and female * Age 18-45 years * Mandibular third molar impaction - all positions * Mandibular third molar impaction - all classes Exclusion Criteria: * ASA status III and above * Patients requiring multiple extractions in the same appointment * Allergy to lignocaine * Patients in whom adrenaline is contraindicated * Medically compromised individuals e.g. poorly controlled diabetes, hypertension
Where it's running
-
Dr Aimen Zafar
Islamabad, Pakistan Recruiting
Study contacts
- Study coordinator: dr aimen zafar Aimen zafar, bds
- Email: aimenali216@gmail.com
- Phone: +923361056720
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.