Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Adding a distolingual injection to standard nerve blocks for lower wisdom tooth removal

Official title: Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar

Run by Watim Medical & Dental College · NCT07296926 · Data updated 2026-11-12

This will test whether adding a distolingual injection to the usual inferior alveolar and buccal nerve blocks reduces pain during lower wisdom tooth extraction in healthy adults aged 18–45.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment120 (estimated)
SponsorWatim Medical & Dental College
Academic / other
Locations1 site (Islamabad)
StatusRecruiting
StartedAugust 15, 2024
Main results expectedFebruary 15, 2026
Study endsApril 15, 2026
Registry record updatedJanuary 6, 2026
Trial IDNCT07296926 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are otherwise healthy adults (18–45 years) with an impacted mandibular third molar requiring extraction who are ASA I–II, not allergic to lignocaine, and able to attend the Islamabad clinic.

Probably not a fit

Patients who are medically compromised (ASA III+), allergic to lignocaine, have contraindications to adrenaline, or require multiple extractions in one appointment are unlikely to qualify or benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will enroll 120 patients requiring mandibular third molar extraction and randomize them to conventional inferior alveolar and buccal nerve blocks alone or the same blocks plus an additional distolingual infiltration. Pain during mucoperiosteal flap elevation and bone guttering will be recorded on a 0–10 Visual Analogue Scale. The primary comparison is intraoperative pain scores between the two groups to see if the extra infiltration improves anesthesia of the distolingual gingiva. Key exclusions include ASA III or higher, allergy to lignocaine, contraindication to adrenaline, and patients requiring multiple extractions in the same appointment.

Why it matters

Potential benefit: If successful, adding a distolingual infiltration could provide more complete numbness of the distolingual gingiva, reducing intraoperative pain and the need for rescue injections.

How similar studies have gone: Previous clinical reports and small series suggest supplemental distolingual infiltration can improve anesthesia for the distolingual gingiva, but randomized controlled data are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Healthy individuals

  * Male and female
  * Age 18-45 years
  * Mandibular third molar impaction - all positions
  * Mandibular third molar impaction - all classes

Exclusion Criteria:

* ASA status III and above

  * Patients requiring multiple extractions in the same appointment
  * Allergy to lignocaine
  * Patients in whom adrenaline is contraindicated
  * Medically compromised individuals e.g. poorly controlled diabetes, hypertension

Where it's running

  • Dr Aimen Zafar
    Islamabad, Pakistan
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.