Forced diuresis with furosemide to reduce leftover stone fragments after flexible ureteroscopy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Flexible ureteroscopy with laser is a common method to break kidney stones into small fragments, but some micro‑fragments often remain in the kidney after the procedure. This Phase 3 interventional trial gives a 40 mg injection of furosemide together with intravenous hydration during the procedure to produce forced diuresis and increase urine flow through the renal cavities. The aim is to reduce the rate of residual fragments left in the kidney at the end of surgery compared with usual care. Eligible patients are adults aged 18–79 undergoing flexible ureteroscopy who do not have contraindications to furosemide such as severe electrolyte disturbances, hypovolemia, or renal failure with oligo‑anuria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients ≥ 18 years old and \< 80 years old
* With the need to perform a flexible ureteroscopy with destruction of the kidney stones with laser
* Participants covered by or entitled to social security
* Written informed consent obtained from the participant
* Ability for participant to comply with the requirements of the study

Exclusion Criteria:

* Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, minors, and persons subject to a legal protection measure: guardianship or trusteeship)
* Contra-indication to Furosemide:

  * Hyper-sensitivity to the active substance or one of the excipients
  * Hyper-sensitivity to Sulfonamide
  * Renal failure with oligo-anuria refractory to Furosemide
  * Hypokalemia \< 3,5 mmol/L
  * Severe hyponatremia
  * Hypovolemia with or without hypotension or dehydration
  * Ongoing hepatitis, hepatic insufficiency severe and hepatic encephalopathy
* Patient having Furosemide as usual treatment
* Patient requiring an injection of Aminoside or Vancomycin before or during the procedure
* Participation in other interventional research with an investigational drug or medical device

Where it's running

• CHU d'Angers
  Angers, France Recruiting
• Hospices Civils de Lyon
  Lyon, France Recruiting
• CHU de Nice
  Nice, France Recruiting
• CHU de Nîmes
  Nîmes, France Recruiting
• CHU de Rennes
  Rennes, France Recruiting
• CHU de Rouen
  Rouen, France Recruiting

Study contacts

• Study coordinator: Marie-Lou LETOUCHE, MD
• Email: marielou.letouche@gmail.com
• Phone: +33247474665

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.