IV paracetamol and blood pressure in adults having emergency laparotomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for emergency laparotomy who are ASA I–III and hemodynamically stable will be randomized to receive IV paracetamol or placebo after standardized induction and maintenance of anesthesia. Preoperative fluid optimization will use passive leg raising to guide stroke-volume–directed boluses, and anesthesia will follow a set regimen (propofol, fentanyl, succinylcholine, isoflurane, atracurium). Heart rate and blood pressure will be recorded every 2 minutes for 20 minutes after drug administration, and predefined hypotension will be treated with 5-µg norepinephrine boluses repeated as needed. The trial excludes patients with significant cardiac disease, ongoing hemodynamic instability, high shock index, pregnancy or lactation, and drug allergies, and is conducted at Cairo University in Cairo, Egypt.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients, ASA I-III undergoing emergency laparotomy

Exclusion Criteria:

* Severe cardiac morbidities (impaired contractility with ejection fraction \< 40%, heart block, arrhythmias, tight valvular lesions)
* Hemodynamically unstable patients (defined as patients with MAP \< 65 mmHg or need vasopressor to maintain MAP\>65 mmHg).
* Patients with high shock index (heart rate / systolic blood pressure \>1)
* Pregnant or lactating women,
* Allergy of any of the study drugs

Where it's running

• Cairo University
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Maha Mostafa
• Email: maha.mostafa@cu.edu.eg
• Phone: +201000365115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• 5 vs 10 mcg norepinephrine bolus for postinduction hypotension in emergency abdominal surgery

  Researchers are testing whether a 5 mcg norepinephrine bolus works as well as a 10 mcg bolus to treat low blood pressure right after induction in patients undergoing emergency abdominal surgery.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07719075

• How paracetamol and cefazolin behave in normal-weight and overweight children

  This study will test how paracetamol and cefazolin move through the body in children aged 2–15 who are normal weight or overweight during minor elective surgery.

  Recruiting University Hospital, Ghent · Ghent · NCT07585487

• Supra- versus infra-inguinal fascia iliaca blocks for easier spinal positioning and pain relief in lower limb surgery

  This test will compare two ultrasound-guided fascia iliaca nerve blocks to see which helps adults aged 30–60 with thigh or knee fractures have less pain and easier positioning for spinal anesthesia.

  Recruiting Phase 2/3 Sahiwal medical college sahiwal · Sāhīwāl, Punjab Province · NCT07221682

• Outcomes of VV-ECMO during emergency thoracic surgery

  This project tries to compare outcomes for adults who receive veno-venous ECMO during or after emergency chest surgery with patients who receive VV-ECMO for medical respiratory failure.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07016685

• Effects of hemoglobin levels on kidney injury after emergency surgery

  This study is testing if having higher hemoglobin levels before emergency surgery can help prevent kidney injury in patients after the operation.

  Recruiting Samsun University · Samsun · NCT06857630

• Whether intense pain before emergency surgery leads to long-term pain after the operation

  We will test whether people having emergency abdominal or orthopedic surgery who have strong pain before the operation are more likely to have ongoing pain three months afterward.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06555107

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.