2-Minute Step Test in Women with Lipedema
Official title: Construct Validity and Reliability of the 2-Minute Step Test in Patients With Lipedema: A Cross-Sectional Study
Run by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · NCT07752017 · Data updated 2026-11-12
This study tests whether the 2-Minute Step Test can reliably measure functional capacity in women with lipedema.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 55 (estimated) |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital Government |
| Locations | 1 site (Istanbul, Bahcelievler) |
| Status | Recruiting |
| Started | August 10, 2026 |
| Main results expected | April 10, 2027 |
| Study ends | April 10, 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07752017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–65 with lipedema (stage 2 or higher) who can walk without limiting conditions.
✕Probably not a fit
Patients with uncontrolled medical conditions or other lower-extremity diseases that affect function may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cross-sectional study will enroll 55 women with lipedema (stage 2 or higher) to compare the 2-Minute Step Test with established measures of function and pain. Participants will complete the 2MST, 6-Minute Walk Test, Timed Up and Go, pain rating, and a lower-extremity function survey, with vital signs recorded before testing. The 2MST will be repeated after 7 days by the same examiner to assess test-retest reliability, using ICC, SEM, and MDC95. Construct validity will be explored through correlations between the 2MST and other functional and pain measures. All tests will be administered in a fixed order by a single examiner, with standardized rest and timing.
Why it matters
Potential benefit: If valid, the 2MST could offer a simple, low-cost test to monitor functional capacity in lipedema patients.
How similar studies have gone: Few studies have tested the 2MST in lipedema, making this largely exploratory but aligned with broader test-validation efforts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinically diagnosed with lipedema according to the Wold and Halk-Damstra criteria, stage 2 and above * Aged 18-65 years, female * No walking-limiting pathology * Willing to participate Exclusion Criteria: * Uncontrolled hypertension * Decompensated cardiac failure * Systemic, degenerative, neurological, rheumatological, or orthopedic disease affecting lower-extremity function * Lower-extremity surgery within the past 6 months * Peripheral artery disease causing vascular claudication * Severe psychiatric disorder (active psychosis, severe major depression) or cognitive impairment preventing compliance with test instructions * Neuromuscular disease * Pregnancy * Advanced-stage lipo-lymphedema severely restricting ambulation
Where it's running
-
İstanbul Physical Medicine and Rehabilitation Research and Training Hospital
Istanbul, Bahcelievler, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Nurdan Paker, Prof — Istanbul Physical Medicine Rehabilitation Training and Research Hospital
- Study coordinator: Merve Aydın, MD
- Email: merveay9702@gmail.com
- Phone: 2124445434
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Manual and self-lymphatic drainage with exercise for lipedema
This study tests whether manual lymph drainage plus supervised exercise works better than self-lymph drainage plus guided activity for reducing pain and improving function in women with lipedema over six weeks.
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Turkish version of the Duke Activity Status Index in women with lipedema
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.