Sponsor or institution
Clinical trials and research at Upstate Medical University
As of November 12, 2026, Find a Trial lists 122 NIH-funded research projects at this institution, with $51.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 122NIH research projects
NIH-funded research (newest 40 of 122)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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How the left-right body axis forms during early development
This project explores how the left-right body axis is set up in early embryos, aiming to understand and prevent birth defects related to organ placement.
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Unraveling how Ribosome Production Is Regulated in Human Cells
This grant explores how the enzyme that makes ribosomal RNA is put together and controlled, with potential connections to cancer and Treacher Collins Syndrome.
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Defining immune markers predicting protection against dengue in a long-term family study in Thailand
This grant looks at how antibodies develop to protect against dengue in children from a long-running family cohort in Thailand, with the goal of identifying immune signs that predict protection across multiple dengue serotypes.
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Understanding dengue protection in children from a long-term Thai family cohort
A long-term study in Thailand follows families to understand how early exposures to dengue shape protection and illness risk for children as they encounter the virus over time.
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SLE treatment with N-acetylcysteine for lupus patients
This project tests whether N-acetylcysteine, a safe supplement, can help people with systemic lupus erythematosus by supporting the body's natural defenses and reducing disease activity.
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Synaptopathy and CYLD in Frontotemporal Dementia (FTD)
A new NIH-funded project will look at how CYLD gene changes contribute to synapse problems in people with frontotemporal dementia.
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Nonstimulant-First vs Stimulant-First ADHD Treatment in Adults
This trial tests whether starting ADHD treatment with a nonstimulant medication works as well as starting with a stimulant for adults with ADHD.
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HLA-Independent CD8+ T Cell Immunotherapy for AML using β-Catenin and NKG2D
A new AML immunotherapy aims to boost patients’ CD8+ T cells by increasing NKG2D activity through stabilizing β-catenin, helping kill leukemia cells even when HLA is reduced.
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Brain gene editing with safe lipid nanoparticles
A new approach uses tiny fat-based particles to deliver gene editing tools to the brain to help treat neurological diseases.
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How neuromodulation may help headaches after a mild brain injury
A small study tests whether stimulating the brain with a noninvasive technique can lessen persistent headaches in people who recently had a concussion.
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Molecular secrets of how photoreceptors renewal their outer segments
This NIH grant supports research to understand how the light-detecting parts of the eye renew themselves, which is crucial for long-term vision and could lead to new treatments for inherited retinal diseases.
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Role of cellular memory in glaucoma
Scientists are studying how eye cells in glaucoma “remember” mechanical stress and stay diseased even after conditions improve, with the goal of finding ways to prevent ongoing eye pressure damage.
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Understanding how kidney-like blood flow may cause amyloid buildup
A research project uses tiny blood-flow devices to study how certain proteins misfold and form amyloid deposits in organs like the kidney and heart.
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Ethanol and brain signaling: finding ways to protect developing brains
A study in young brains explores how alcohol exposure during pregnancy may disrupt key signaling pathways and how we might protect fetal brain development.
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Correlates of protection from dengue in a long-term family cohort in Thailand
This project looks at how children’s early exposure to flaviviruses shapes protection against dengue for future infections in a long-running family cohort in Thailand.
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Sulfonium lipid nanoparticles as a new platform for mRNA delivery
A new type of lipid nanoparticle using sulfonium heads is being developed to deliver mRNA and may help treat acute lung injuries like ARDS.
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From variants to mechanisms for cardiac arrhythmias
A project to understand how genetic differences contribute to heart rhythm problems by studying how gene regulation affects heart cells.
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Understanding how actin and microtubules work together in cancer cells
Researchers are studying how cell skeletons called actin and microtubules are built and coordinated to affect cancer cell behavior.
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Targeting a brain circuit to help memory in Alzheimer’s disease
A study aims to understand a brain pathway involving serotonin that may help improve memory problems in people with Alzheimer’s disease.
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Brain gene activity across ancestries in schizophrenia
Researchers are comparing brain gene activity from people of East Asian, African/African American, and European ancestry to help explain genetic links to schizophrenia.
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Understanding how cells make ribosomal RNA
Learning how the cell's RNA-making machinery (Pol I) works could help people with certain cancers and developmental disorders.
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B cell receptors may drive dengue infection and severity
A study from Upstate Medical University explores how B cells and their receptors might influence dengue virus infection and the body’s response in people who get dengue.
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How gut bacteria shape your antibody defenses
This grant explores how good gut bacteria help your body produce protective antibodies, with a focus on people who may be at risk for diabetes and other inflammation-related conditions.
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How the TBX3 gene affects blood vessel growth in the retina
This work explores whether changes in the TBX3 gene change how retinal blood vessels form in people with conditions like retinopathy of prematurity and familial exudative vitreoretinopathy.
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Assessing mouse retinal vision with AI and precise recordings
A scientist plans to use advanced brain recordings in mice and machine learning to test how well vision restoration methods might work.
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Blood-brain barrier leak and inflammation in schizophrenia and dopamine changes
A NIH-supported project will study brain tissue from people with schizophrenia to understand how inflammation affects the barrier between the blood and brain and how this relates to dopamine changes.
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How the size of nerve fibers controls brain myelin length
A scientist team is studying how the width of nerve fibers influences the length of protective myelin sheaths in the CNS, which could reveal new ways to help people with neurological diseases.
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Rabbit model of KCNH2-related epilepsy, SUDEP, and Long QT syndrome type 2
Researchers are creating rabbits with a human-like KCNH2 gene change to help find safer seizure treatments and reduce sudden-death risk for people with KCNH2-related epilepsy and Long QT syndrome.
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Understanding a Brain Connection for Alzheimer's Memory
This research explores how a specific brain connection involving serotonin might help improve memory problems in people with Alzheimer's disease.
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How CasL helps T cells move
This project looks at how a protein called CasL helps immune T cells sense mechanical signals and move, which could affect inflammation and cancer.
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Mitochondria–lysosome stress in aging and Alzheimer’s disease
This project looks at how stress signals between mitochondria and lysosomes harm brain cells in Alzheimer's and other age-related diseases to guide future treatments.
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Why people with frontotemporal dementia lose empathy
This work looks at whether problems in a brain area called the dorsomedial prefrontal cortex cause people with behavioral frontotemporal dementia to lose empathy.
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Nanoparticle medicine to calm dangerous inflammation in sepsis
A tiny, targeted medicine that aims to soak up excess inflammatory molecules and calm life-threatening inflammation in people with sepsis and related conditions.
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How the cell acid 'pumps' (V-ATPases) work and affect disease
This work explores how tiny cellular proton pumps and their helper proteins function because changes in them can contribute to epilepsy, dementia, and some cancers.
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Immune system's role in repairing the retina
Testing whether changing immune activity can help retinal support cells regrow neurons to restore vision for adults with retinal injury or degeneration.
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Phase separation of the MLL1 core complex catalytic module
A new approach studies how a key leukemia-related protein complex organizes itself in the cell to drive aggressive blood cancers, with potential implications for future therapies.
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How optic nerve support cells respond to pressure in glaucoma
This project looks at whether brief pressure strains make the optic nerve's support cells more likely to drive damage in people with glaucoma.
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Lung-targeted immune-boosting mRNA therapy for ARDS
A lung-targeted IL-10 mRNA therapy delivered by a special lipid nanoparticle is being explored to calm inflammation in adults with ARDS.
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How light-sensing cells build their outer, light-catching discs
This work watches how photoreceptor cells move the rhodopsin protein to make and maintain the light-detecting discs that keep vision working, with implications for people with inherited or degenerative retinal disease.
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How the cell 'cleanup' system (ubiquitin) affects corneal scarring
This work looks at whether blocking a protein called USP10 can reduce scarring after cornea injury to help protect or restore vision.
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