From variants to mechanisms for cardiac arrhythmias
Funded at Upstate Medical University · NIH-11386349 · Data updated 2026-11-12
A project to understand how genetic differences contribute to heart rhythm problems by studying how gene regulation affects heart cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $760,778 |
| NIH project number | 5R01HL170051-05 |
| Project ID | NIH-11386349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with arrhythmias or at risk due to genetic factors who provide heart tissue samples or participate in related studies.
✕Less likely to help
People without arrhythmias or genetic risk factors may not directly benefit from this project.
What this research studies
This grant focuses on linking genetic variants associated with arrhythmias to their underlying biology in human heart tissue. Researchers will use CRISPR-based gene-modification tools in heart cells to see how changes in transcription factors alter electrical activity. They will profile changes in gene expression and protein levels to map the pathways that lead to arrhythmias. The work includes analyzing human atrial tissue with advanced sequencing techniques to connect genetics to function. The goal is to identify new mechanisms that could be targets for therapy.
Why it matters
Potential benefit: If successful, this work could identify new molecular targets to prevent or treat arrhythmias.
How similar studies have gone: Previous studies have shown that linking genetic variants to functional changes in heart cells can reveal actionable pathways, though much remains to be discovered.
Where this research is happening
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Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Tucker, Nathan R — Upstate Medical University
- Study coordinator: Tucker, Nathan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.