B cell receptors may drive dengue infection and severity
Official title: B cell receptor dependent infection as a mechanism of immune-mediated enhancement of dengue virus infection and pathogenesis
Funded at Upstate Medical University · NIH-11369986 · Data updated 2026-11-12
A study from Upstate Medical University explores how B cells and their receptors might influence dengue virus infection and the body’s response in people who get dengue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | July 7, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $633,780 |
| NIH project number | 5R01AI192874-02 |
| Project ID | NIH-11369986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with dengue infection or individuals at risk of dengue who are being studied for immune responses.
✕Less likely to help
As the research is mechanistic, direct benefits to individual patients during the study may be limited.
What this research studies
This project looks at how dengue-specific B cell receptors could make B cells more likely to be infected, potentially shaping immune-mediated disease. Researchers plan to use human samples and cellular models to understand how B cells contribute to dengue pathology. The findings could point to new ways to prevent severe dengue by targeting B cell pathways. The study is anchored in human-relevant biology and aims to translate basic insights into strategies for reducing severe outcomes.
Why it matters
Potential benefit: If successful, the work could lead to novel approaches to prevent or lessen severe dengue by modulating B cell responses.
How similar studies have gone: Previous work shows B cells can harbor dengue and influence infection; this study adds a specific B cell receptor perspective which is exploratory but builds on known biology.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Waickman, Adam T — Upstate Medical University
- Study coordinator: Waickman, Adam T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.