Understanding dengue protection in children from a long-term Thai family cohort
Official title: Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
Funded at Upstate Medical University · NIH-11563693 · Data updated 2026-11-12
A long-term study in Thailand follows families to understand how early exposures to dengue shape protection and illness risk for children as they encounter the virus over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $94,253 |
| NIH project number | 3R01AI175941-04S1 |
| Project ID | NIH-11563693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children in dengue-endemic regions who are part of the ongoing Kamphaeng Phet multigenerational cohort and have documented dengue exposure history.
✕Less likely to help
Children outside dengue-endemic areas or not enrolled in the cohort are unlikely to directly benefit.
What this research studies
This project uses data and samples from a multigenerational cohort in Kamphaeng Phet to map how early flavivirus exposures influence dengue antibody patterns and later illness outcomes. Researchers will track primary and subsequent dengue infections, measure antibody levels, and compare immune responses across different ages and exposure histories. The goal is to identify immune markers that predict protection against multiple dengue serotypes and more severe disease, helping guide future vaccines and public health strategies. Participation involves ongoing monitoring of families already enrolled in the cohort, with analyses of immunological data and clinical outcomes.
Why it matters
Potential benefit: If successful, the study could clarify which immune responses best protect against dengue and inform more effective vaccines and public health interventions for children.
How similar studies have gone: Previous work shows that natural exposure can shape durable, multi-typic immunity, supporting the potential relevance of this approach.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Anderson, Kathryn B — Upstate Medical University
- Study coordinator: Anderson, Kathryn B
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Defining immune markers predicting protection against dengue in a long-term family study in Thailand
This grant looks at how antibodies develop to protect against dengue in children from a long-running family cohort in Thailand, with the goal of identifying immune signs that predict protection across multiple dengue serotypes.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.