Using laser technology to improve anal cancer screening for HIV-positive patients

Raman-enhanced spectroscopy (RESpect) for anal dysplasia in HIV-positive patients

['FUNDING_R21'] · UNIVERSITY OF HAWAII AT MANOA · NIH-9856763

This study is testing a new, gentle way to check for anal dysplasia in people with HIV, using a special laser technique that could make screenings easier and more comfortable than the usual methods.

Quick facts

Phase['FUNDING_R21']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF HAWAII AT MANOA (nih funded)
Locations1 site (HONOLULU, UNITED STATES)
Trial IDNIH-9856763 on ClinicalTrials.gov

What this research studies

This research investigates a new method called Raman-enhanced spectroscopy (RESpect) to screen for anal dysplasia in HIV-positive individuals, who are at a significantly higher risk for anal cancer. The study aims to develop a less invasive alternative to current screening methods, which often involve uncomfortable biopsies. By analyzing the chemical composition of cells and tissues with laser technology, the research seeks to provide a more accurate and patient-friendly screening option. This innovative approach could lead to better prevention strategies for anal cancer in this vulnerable population.

Who could benefit from this research

Good fit: Ideal candidates for this research are HIV-positive individuals, particularly men, who are at high risk for anal dysplasia and cancer.

Not a fit: Patients who are not HIV-positive or those who do not have a history of anal dysplasia may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to a more effective and less invasive screening method for anal cancer, improving early detection and patient outcomes.

How similar studies have performed: While the use of Raman-enhanced spectroscopy is a novel approach in this context, similar technologies have shown promise in other areas of cancer detection.

Where this research is happening

HONOLULU, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Cancers, neoplasm/cancer

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.