What keeps our microbiome steady during infections
Official title: Determinants of Microbiome Stability Following Pathogen Infection
Funded at University of Hawaii at Manoa · NIH-11392487 · Data updated 2026-11-12
This grant looks at how our body’s microbial communities stay stable when a pathogen hits, which could help keep infections milder and protect health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | August 15, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $162,891 |
| NIH project number | 5P20GM125508-09 |
| Project ID | NIH-11392487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals experiencing or at risk for infections where microbiome stability is a concern, across diverse ages and backgrounds.
✕Less likely to help
People not experiencing infections or microbiome disturbances may not directly benefit from this research.
What this research studies
This project investigates why the microbiome resists or recovers from disturbances like infections and temperature changes. It focuses on how the mix of microbes and their functions influence stability and health outcomes. Researchers will study how climate-related stresses and pathogen infections interact to affect the microbiome in humans, aiming to uncover factors that promote resilience. The findings could guide strategies to preserve or restore a healthy microbiome during illness or environmental stress.
Why it matters
Potential benefit: If successful, the work could lead to ways to maintain a healthy microbiome during infections, potentially improving recovery and overall health.
How similar studies have gone: Previous studies show microbiome changes during infection can impact health, but this project explores stability under combined stressors like pathogens and temperature.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Jani, Andrea — University of Hawaii at Manoa
- Study coordinator: Jani, Andrea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.