Understanding why DCIS becomes invasive breast cancer in Asian American and Native Hawaiian/Pacific Islander groups
Official title: Identification of Biological Mechanisms and Risk Factors Contributing to Progression of DCIS to Invasive Breast cancer among AANHPI Populations.
Funded at University of Hawaii at Manoa · NIH-11449258 · Data updated 2026-11-12
A research project aims to identify biological factors and risk patterns that predict when early-stage DCIS may progress to invasive breast cancer, with a focus on AANHPI populations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | August 13, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $555,703 |
| NIH project number | 1R01CA301785-01A1 |
| Project ID | NIH-11449258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with DCIS, especially those identifying as Asian American or Native Hawaiian/Pacific Islander, who are willing to share clinical, lifestyle, and tumor data for follow-up.
✕Less likely to help
Patients with DCIS who do not progress to invasion may see limited immediate benefit if risk stratification does not change their treatment.
What this research studies
This project follows people with ductal carcinoma in situ (DCIS) to find markers and risk factors that distinguish indolent cases from those likely to progress to invasive cancer, especially in Asian American and Native Hawaiian/Pacific Islander groups. Researchers will analyze clinical data, tumor characteristics, lifestyle factors, and sociodemographic information to identify high-risk profiles. The study uses follow-up of patients treated for DCIS to understand long-term outcomes and potential disparities. By clarifying who is at higher risk, doctors could tailor treatment to reduce over- or under-treatment.
Why it matters
Potential benefit: If successful, the project could lead to more personalized DCIS treatment plans that prevent overtreatment and improve early detection of progression for at-risk patients.
How similar studies have gone: Prior work suggests racial/ethnic differences exist in DCIS progression, supporting the potential for meaningful findings with larger multiethnic analyses.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Loo, Lenora Wm — University of Hawaii at Manoa
- Study coordinator: Loo, Lenora Wm
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.