Long-term safety and effectiveness of Dengvaxia in the Philippines
Funded at University of Hawaii at Manoa · NIH-11418098 · Data updated 2026-11-12
This project watches how Dengvaxia behaves in real life in Filipino children over many years to understand safety and how well it protects against dengue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $503,085 |
| NIH project number | 5R01AI186073-03 |
| Project ID | NIH-11418098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children in the Philippines who received Dengvaxia and are being monitored for long-term safety and immune responses.
✕Less likely to help
Children who did not receive Dengvaxia or those not enrolled in observational follow-up are unlikely to benefit directly.
What this research studies
This grant studies the long-term safety and effectiveness of the Dengvaxia dengue vaccine in a real-world setting in the Philippines. Researchers will examine antibody and T-cell responses, including antibody titers, in children who received the vaccine, especially those who may have only completed 1-2 doses. The work builds on prior findings about serostatus and breakthrough infections to clarify risk of severe disease and waning protection. Findings could guide future vaccination strategies and post-licensure monitoring to protect children.
Why it matters
Potential benefit: Better understanding of how Dengvaxia performs over time could improve safety and vaccination guidelines for children in dengue-endemic areas.
How similar studies have gone: Previous work has shown waning efficacy and complex antibody responses; this study builds on a feasible, clinically relevant approach.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Wang, Wei-Kung — University of Hawaii at Manoa
- Study coordinator: Wang, Wei-Kung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.