NIH-funded research NIH-funded research

Lifestyle change program study for people using GLP-1 medications

Official title: Lifestyle Change Implementation Research Network at PRC at UMass Chan

Funded at Univ of Massachusetts Med Sch Worcester · NIH-11422056 · Data updated 2026-11-12

A patient-focused study will test a digital lifestyle-change program called Noom to help people using GLP-1 therapies improve activity, eating habits, and overall health.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniv of Massachusetts Med Sch Worcester
NIH-funded
Lab location1 site (Worcester, United States)
Project startSeptember 30, 2025
Project endSeptember 29, 2029
Funding year2026
Award (this year)$510,893
NIH project number5U48DP006955-02
Project IDNIH-11422056 on NIH RePORTER

Who could benefit from this research

Could help

Adults currently using GLP-1 medications for weight management, diabetes, or cardiovascular risk reduction.

Less likely to help

People not using GLP-1s or those unwilling to engage with a digital lifestyle program may not benefit.

What this research studies

This project will set up two centers to study how well Noom works for people taking GLP-1 medications for weight loss, diabetes, or heart disease. In the initial phase, adults on GLP-1s will be randomized to a 4-month Noom program or usual care, with goals like more physical activity and healthier eating. Researchers will track changes in activity, diet quality, body measurements, and health markers over time. The study also looks at how easily clinics, providers, and patients can adopt and sustain the digital program in real-world settings.

Why it matters

Potential benefit: If successful, patients using GLP-1s could have a proven digital tool to help achieve better weight, activity, and cardiovascular health.

How similar studies have gone: Digital lifestyle programs have shown promise, but evidence in GLP-1 users is limited and this study provides new implementation data.

Where this research is happening

  • Univ of Massachusetts Med Sch Worcester
    Worcester, United States
    Active

Researchers

  • Principal investigator: Faro, Jamie — Univ of Massachusetts Med Sch Worcester
  • Study coordinator: Faro, Jamie

Related research

Other NIH-funded projects on the same topics.

  • Understanding HIV-1 Env shapes to boost immune attack against infected cells

    Aimed at helping people living with HIV, this project explores how specific HIV-1 envelope structures attract or resist immune attack so future therapies could better help the body clear hidden virus.

    NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11620068

  • Reprogramming metabolism to power alternative fat-burning modes

    A new project will explore how fat cells burn calories in different ways to help combat obesity.

    NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11607804

  • Silencing an Extra Chromosome to Help Down Syndrome and Related Conditions

    A patient-friendly plan to use a gene-based approach to quiet an extra chromosome in cells and a mouse model to reduce disease-related effects in Down syndrome and other chromosomal imbalance disorders.

    NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11600903

  • Gut microbes and brain function in autism

    Researchers are exploring how gut bacteria may influence brain signals and behavior in autism, using worm models to uncover possible links that could someday inform human therapies.

    NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11594150

  • Chlamydia and gonorrhea interaction: how host interferons influence co-infection

    A human-health focused project looks at how the body’s interferon signals during chlamydia infection affect the way gonorrhea behaves, with potential implications for people vulnerable to both infections.

    NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11572329

  • Conquering High Blood Pressure in Vietnamese Cities

    A program to adapt and test a proven plan for lowering high blood pressure in urban Vietnam using a mobile health platform and integrated care approach.

    NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11565070

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.