Helping doctors prescribe blood thinners for atrial fibrillation

SUPPORT-AF IV

NIH-funded research Univ of Massachusetts Med Sch Worcester · NIH-11420052

A new electronic alert for doctors aims to help people with atrial fibrillation get guideline-recommended blood thinners.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of Massachusetts Med Sch Worcester NIH-funded
Lab location1 site (Worcester, United States)
Project IDNIH-11420052 on NIH RePORTER

What this research studies

If you have atrial fibrillation, the project adds a prompt in your doctor's electronic health record when you have high stroke risk and are not on anticoagulation. The alert will be used in cardiology clinics at two health systems and the team will track whether clinicians start more patients on recommended blood thinners. Researchers will study how clinicians respond to the alert using interviews and EHR access logs, then improve the alert based on what they learn. They will also create a toolkit so other hospitals can adopt the alert.

Who could benefit from this research

Good fit: Ideal candidates are people with atrial fibrillation who have elevated stroke risk, are not currently on oral anticoagulants, and receive cardiology care at one of the participating health systems.

Not a fit: People already taking guideline-recommended anticoagulants, those with clear contraindications to anticoagulation, or those cared for outside the participating systems are unlikely to benefit directly from this project.

Why it matters

Potential benefit: If successful, more people with atrial fibrillation could receive appropriate anticoagulants and have a lower risk of stroke and related disability.

How similar studies have performed: Previous EHR alert and decision-support efforts have shown mixed but often promising improvements in anticoagulant prescribing, and this project builds on those approaches with enhanced alerts and implementation support.

Where this research is happening

Worcester, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.