Sponsor or institution
Clinical trials and research at Tufts University Medford
As of November 12, 2026, Find a Trial lists 64 NIH-funded research projects at this institution, with $31.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 64NIH research projects
NIH-funded research (newest 40 of 64)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Lactobacillus helpers to support healthy pregnancies
A small study will test how friendly vaginal bacteria produce anti-inflammatory compounds that may protect pregnancy by reducing harmful inflammation.
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Rapid, at-home test for galactosemia biomarker gal-1P
A new sensor device will let people with classic galactosemia and their caregivers monitor gal-1P levels at home or in clinics.
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Targeted lysosomal RNA degradation for disease-relevant RNAs
A new approach uses tiny molecules to tag specific RNAs for destruction inside cells, with the goal of helping diseases linked to RNA problems.
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Chemical tools to map how glycation and ubiquitination control cell signals in cancer and aging
A researcher team is developing new chemical methods to watch how specific protein modifications like glycation and ubiquitination shape cell signaling in living human cells, aiming to uncover targets to prevent or treat cancer and age-related diseases.
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How Stress Shapes the Brain and Health in Everyday Life
This NIH grant funds a study to understand how stress from daily life affects the brain and body and contributes to health problems like depression, anxiety, heart disease, and diabetes.
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Graph-tools for uncovering redundant genetic pathways in cancer biology
A research team will build new graph-based methods to map how genes work together in cancer-related networks, helping predict what happens when genes are turned off or stressed.
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From risk to resilience: How extreme weather affects health in Gulf and Southeast US communities
A multi-disciplinary study will map how extreme weather hurts health in Gulf and Southeastern US coastal communities and identify factors that make places more vulnerable or more resilient.
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Advanced methods to predict how tightly drugs stick to targets
Researchers are developing new computer-based methods to predict how strongly potential drugs will bind to their targets, to speed up drug design for patients.
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How cells adapt to stiffness and what that could mean for breast cancer
Scientists will study how breast cancer cells change over time when grown on soft versus stiff surfaces to see if their genetics shift to favor growth in those conditions.
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Culturally adapted mobile program to help manage high blood pressure in urban and rural Ghana
This project uses a mobile phone app and text messages tailored for Ghana to help adults with high blood pressure communicate with their care team and manage their blood pressure.
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Targeting the cell's recycling system to remove harmful proteins and help large medicines enter cells
Researchers are designing new molecules that hijack cells' recycling machinery to break down disease-causing proteins and improve delivery of large medicines for people with advanced cancers.
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Understanding how the tissue environment controls scarring and fibrosis in infections
This grant studies how the surrounding tissue matrix and virus- or bacteria-related inflammation can cause fibroblasts to stay active and contribute to fibrosis, which can harm organs after infections.
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Ingestible micro-pill to sample gut content from chosen GI sites
A tiny swallowable device will automatically collect gut samples from specific parts of the intestine, aiming to do so without invasive procedures.
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Air pollution and metals linked to brain aging and dementia in older adults
This study looks at whether air pollution and metals in the brain are connected to dementia and changes in thinking in people aged 21 and up who are part of a long-running aging and dementia study.
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Image-guided oxygen-enhanced photodynamic therapy for head and neck cancer using multifunctional nanodroplets
A new treatment approach uses special nanodroplets and light-activated therapy to target head and neck cancer more precisely while sparing healthy tissue.
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Understanding and designing cyclic peptides for targeting protein interactions
A research project aims to design cyclic peptides that can modulate protein–protein interactions to enable new therapeutic strategies.
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Dual-slope FD-NIRS to study brain signals non-invasively
A non-invasive brain imaging method using dual-slope frequency-domain near-infrared spectroscopy to better measure deep brain signals in real-world settings.
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Stress and brain circuits behind how we respond to alcohol
A study in adult rodents will explore how stress changes the way the brain processes alcohol’s unpleasant effects and increases drinking, focusing on a specific brain pathway.
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Understanding how the endometrium resolves inflammation to support fertility and prevent disease
This research will study how the lining of the uterus clears inflammation after events like menstruation to keep reproductive health intact and potentially shed light on conditions like endometriosis.
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Binary PROTAC delivery to trigger targeted protein degradation in cancer
This grant aims to develop new ways to efficiently degrade cancer-causing proteins inside cells using specially designed PROTACs delivered by lipid nanoparticles.
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Multi-modal wearable system to track mobility and thinking in older adults
A wearable sensor system will continuously monitor movement and cognition in people aged 65 and older to help detect early signs of Alzheimer’s disease and related dementias.
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Lung-targeted mRNA therapy for Bourneville-related LAM using specialized lipid nanoparticles
A new lung-focused mRNA therapy using tiny lipid particles aims to slow or stop lung damage in people with lymphangioleiomyomatosis who have mutations in TSC1 or TSC2.
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How repeating DNA sequences expand and cause disease
Researchers are looking at how certain repeating parts of DNA grow and lead to inherited disorders and some cancers.
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How the brain links hearing and movement to sense rhythms
Using songbirds, researchers look at how motor parts of the brain help the hearing system predict rhythms to inform better therapies for people with stroke, Parkinson’s disease, or language and reading problems.
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Switching sodium channel RNA to treat childhood SCN8A epilepsy
Using a targeted genetic medicine called an antisense oligonucleotide (ASO) to change how the SCN8A sodium channel gene is read, hoping to reduce seizures in children with SCN8A-related epileptic encephalopathy.
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Injectable heart-supporting gel to help healing after a heart attack
A new injectable gel made from heart-derived proteins and engineered materials aims to help adults' hearts heal better after a heart attack.
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A home-ready device to meter and separate tiny blood samples for lab testing
A tool to let people collect a small fingerstick blood sample at home that separates and preserves plasma so labs can run many of the same tests as a regular blood draw.
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DNA damage tolerance in cells and tissues to improve cancer therapies
A study to understand how cells cope with DNA damage and how cancer cells rely on special DNA repair steps, with a focus on breast cancer genes and potential targets for therapy.
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DNA repeat structures and genome stability
This project looks at how folded or repeated DNA stretches cause genetic damage that can lead to conditions like Huntington’s disease, aiming to find ways to prevent those harmful changes.
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Why some triple-negative breast cancers resist chemotherapy
This research explores whether changes in the tumor’s surrounding support tissue (the extracellular matrix) and a protein called Cathepsin B change how chemotherapy works for people with triple-negative breast cancer.
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Improving Head and Neck Cancer Treatment with Targeted Light and Oxygen
This project explores a new way to treat head and neck cancer using special light-activated nanoparticles and oxygen to target cancer cells more precisely.
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Mobile support for managing high blood pressure in Ghana
A phone-based program that uses an app and text messages to help people in Ghana manage their high blood pressure.
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How cell repair proteins spot and fix DNA damage linked to cancer
Working to understand how the Shu complex and RAD52 proteins fix DNA damage that can lead to cancer, which matters for people with BRCA2-related risks.
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A Smart Pill for Collecting Gut Samples
This project is creating a tiny, swallowable pill that can collect samples from specific areas of your digestive system without needing invasive procedures.
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Monitoring mobility and cognition in older adults using wearable sensors
This study is testing a new, easy-to-wear device that helps keep track of how older adults move and think, especially those who might be at risk for Alzheimer's, so we can catch any changes in their health early and help them better.
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AI-powered urine test to detect bladder cancer from shed bladder cells
An AI-based urine test will use tiny surface images of bladder cells shed in urine to find bladder cancer and how aggressive it is in people at risk or under surveillance.
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Investigating how plastics affect gut health using advanced models
This study is looking at how tiny plastic particles might affect your gut health by using special 3D models of the intestine, and it's for anyone interested in understanding how these plastics could impact digestion and inflammation in both healthy and sick intestines.
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A pill that samples gut bacteria from specific areas in the intestines
This study is testing a tiny pill that you can swallow, which collects samples from your gut to help doctors learn more about your gut health without needing any invasive procedures.
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Developing specialized nerve and cartilage cells from stem cells
This study is exploring how to turn special stem cells into nerve and cartilage cells to help us learn more about and find better treatments for diseases that affect the nervous system, like multiple sclerosis or ALS.
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Understanding how nerves influence cancer spread
This study is looking at how nerves might help cancer cells spread from their original tumors to other parts of the body, and it's for anyone interested in new ways to prevent or treat cancer by understanding this connection better.
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