Understanding how the endometrium resolves inflammation to support fertility and prevent disease
Official title: Dissecting the Inflammation Resolution Mechanisms in Endometrial Health and Disease
Funded at Tufts University Medford · NIH-11342139 · Data updated 2026-11-12
This research will study how the lining of the uterus clears inflammation after events like menstruation to keep reproductive health intact and potentially shed light on conditions like endometriosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Medford NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | June 1, 2026 |
| Project end | February 28, 2031 |
| Funding year | 2026 |
| Award (this year) | $351,945 |
| NIH project number | 1R01HD121626-01 |
| Project ID | NIH-11342139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with menstrual health concerns or endometriosis, or those seeking to understand endometrial immune responses, may benefit from insights in this research.
✕Less likely to help
People without menstrual health issues are unlikely to directly benefit from the mechanisms studied, though broader immune-resolution knowledge could emerge.
What this research studies
Researchers at Tufts University will examine how specialized molecules that help end inflammation resolve work in the human endometrium, focusing on how estrogen and progesterone influence these processes. The project aims to use human-based models to map the time course of inflammatory signals and their resolution during the menstrual cycle. By linking lipid-based pro-resolving mediators to endometrial function, the study hopes to uncover mechanisms that prevent chronic inflammation and disease. Findings could inform new strategies to improve fertility and address conditions such as endometriosis.
Why it matters
Potential benefit: A better understanding of how endometrial inflammation resolves could lead to new treatments that improve fertility and reduce endometriosis-related pain and dysfunction.
How similar studies have gone: Previous work on inflammatory resolution in human tissues supports the plausibility of identifying key mediators with potential clinical relevance.
Where this research is happening
-
Tufts University Medford
Boston, United States Active
Researchers
- Principal investigator: Gnecco, Juan Sebastian — Tufts University Medford
- Study coordinator: Gnecco, Juan Sebastian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.