A pill that samples gut bacteria from specific areas in the intestines

Ingestible Pill for spatially targeted sampling of gut microbiome

NIH-funded research Tufts University Medford · NIH-11138897

This study is testing a tiny pill that you can swallow, which collects samples from your gut to help doctors learn more about your gut health without needing any invasive procedures.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionTufts University Medford NIH-funded
Lab location1 site (Boston, UNITED STATES)
Project IDNIH-11138897 on NIH RePORTER

What this research studies

This research focuses on creating a small ingestible device called a micro-pill that can autonomously collect samples from specific locations in the gastrointestinal tract. Unlike traditional methods that require invasive procedures, this micro-pill uses sensors to detect pH and oxygen levels to determine when and where to sample intestinal content. It is designed to operate on a battery and can be activated wirelessly, making it suitable for patients with varying gastrointestinal conditions. The goal is to improve the understanding of gut microbiome composition without the need for invasive surgeries.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 years old who may require gastrointestinal sampling for health assessments.

Not a fit: Patients with conditions that prevent them from ingesting pills or those who do not require gastrointestinal sampling may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a non-invasive method for patients to better understand their gut health and microbiome.

How similar studies have performed: While the concept of ingestible devices is not entirely novel, the specific approach of this micro-pill for targeted sampling is innovative and has not been widely tested.

Where this research is happening

Boston, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.