Sponsor or institution
Clinical trials and research at Research Inst of Fox Chase Can Ctr
As of November 12, 2026, Find a Trial lists 117 NIH-funded research projects at this institution, with $62.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 117NIH research projects
NIH-funded research (newest 40 of 117)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Omega-3 dietary supplement profiles for Asian American adults at risk for cardiometabolic diseases
A grant to better understand how omega-3 supplements affect heart and metabolic health in Chinese, Vietnamese, and Filipino adults ages 18–64.
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Targeting the IL-1R Pathway to Boost Immunotherapy for Anaplastic Large Cell Lymphoma
Aims to make CD30 CAR therapies work better for people with ALCL by blocking a immune-evasion pathway.
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How an immune signal in brain support cells helps breast cancer spread to the brain
This project looks at whether a specific immune signal in brain support cells (astrocytes) helps breast cancer cells grow in the brain, aiming to help people with breast cancer that has spread to the brain.
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Intercepting pancreatic cancer by targeting a tumor-supporting network
A patient-facing overview of a funded project that aims to stop pancreatic cancer from progressing by targeting the supportive tissue around tumors.
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Refolding Mutant p53: A Strategy to Help People with Li-Fraumeni Syndrome
Aims to develop drugs that stabilize mutant p53 in people with Li-Fraumeni syndrome to prevent cancers before they develop.
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Informatics Core supports precision cancer research at Fox Chase Cancer Center
A data and stats support program helps cancer researchers design smarter studies and manage high-quality data to speed preventive and early-interception cancer work.
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Administrative Core for CAP-IT Center at Fox Chase Cancer Center
A central, coordinating grant helps Fox Chase Cancer Center run its CAP-IT Center smoothly so researchers can collaborate effectively on hereditary cancer syndromes and related topics.
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Cancer prevention: targeted agents to stop cancer early in high-risk people
A team at Fox Chase Cancer Center is building a pipeline to develop and test targeted drugs that could prevent cancer or catch it early in people with strong hereditary cancer risk.
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BRCA1-mutant cancers: how new PALB2 pathways could overcome resistance to therapy
A research grant is exploring how BRCA1-mutant cancers become resistant to PARP inhibitor therapy by uncovering new PALB2-related mechanisms.
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Asian American Community Health Cohort and Engagement Study (ACCESS)
A large community-based study will enroll over 2,000 Asian American adults to better understand how cardiometabolic health affects this diverse population.
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Linking TCR signal strength to Id3 dynamics in developing T cells
This grant explores how different strengths of T cell receptor signals shape the development of two T cell lineages by studying Id3 transcription and its effect on gene regulation.
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Understanding how human γδ T cells develop and respond in health and disease
A research grant is exploring how a special type of immune cell called γδ T cells learns to develop and act, with potential implications for autoimmune diseases and cancer therapies.
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E protein targets shaping early γδ T cell development and function
A scientist-led project will explore how specific proteins control the development and function of a special type of immune cells called γδ T cells, which are important for keeping us healthy.
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Administrative Core support for a genome-wide study on T cell development
A core grant supports coordinating a multi-site program using genome-wide and single-cell methods to study how T cell signals influence development and how mouse findings relate to human gamma-delta T cells.
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Molecular clues to how a type of immune cell decides its fate
This grant supports research to understand how γδ T cells choose their development path, which could lead to new ways to treat autoimmune diseases.
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How DNA repair and gene regulation work together in cancer
A research team is studying how repairing DNA damage in cancer-related genes can influence how those genes are turned on or off.
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Targeting DHX9 to boost viral-like immune response in Small Cell Lung Cancer
A scientist team is testing whether blocking a protein called DHX9 can make aggressive small cell lung cancer more visible to the immune system and more responsive to immunotherapy.
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Understanding how blood stem cells decide to self-renew or differentiate
A new NIH grant looks at how blood stem cells choose between making more stem cells or becoming mature blood cells, which is important for treating blood diseases.
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Promoting open talks about sexual health after gynecologic cancer
A patient-focused program helps women with gynecologic cancer start and guide conversations about sexual health with their doctors.
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Targeting BCL2 to boost radiation effects in HR+ breast cancer
This grant explores using a BCL2-targeting strategy to make radiation work better against hormone receptor–positive breast cancer in people.
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Targeting ERK’s brake pedals to slow cancer progression
Aims to block the parts of ERK signaling that speed up cancer progression, by guiding drugs to the substrate-binding domains that act like accelerator pedals in myeloproliferative neoplasms and related cancers.
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Fibroblasts in brain metastases help cancer grow and hide from treatment
In people with cancer that has spread to the brain, researchers are studying how lung cancer–driven fibroblasts in the brain help cancer cells grow, resist standard therapies, and dampen the immune response.
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Blood tests to predict who will respond to pre-surgery therapy for locally advanced rectal cancer
A blood-based test is being developed to predict which patients with locally advanced rectal cancer will respond to neoadjuvant chemoradiation before surgery.
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Pancreatic cancer’s scar-forming cells: what they do and how we might guide them to help patients
A cancer research grant is studying the scar-forming cells in pancreatic tumors to understand how they affect tumor growth and how we might steer them toward helping patients.
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Telomerase RNP: How it controls cell aging and cancer
A research grant is exploring how the telomerase enzyme influences aging and most cancers, with the hope of finding new ways to treat cancer or protect healthy cells.
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How the ERG protein drives prostate cancer growth and invasion
This work looks at how a common protein called ERG changes prostate cancer cells and whether targeting a linked pathway could lead to new treatments for men with ERG-positive prostate cancer.
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How DNA folds inside cells and how that affects cancer
Researchers are looking at how the cell's DNA-folding machinery shapes the genome in three dimensions and how problems in that process relate to cancer.
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How Salmonella biofilms and the host protein ZBP1 may cause reactive arthritis
This work looks at how bacterial biofilms from Salmonella and a human protein called ZBP1 can spark immune reactions that sometimes cause long-lasting joint pain after a gut infection.
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Using thyroid hormone to make medulloblastoma cells mature and stop growing
Looks at whether thyroid hormone can make medulloblastoma cells mature and slow tumor growth in children with this type of brain cancer.
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Residential history in midlife and prostate cancer outcomes
This grant looks at how where people live in midlife affects their prostate cancer outcomes and survival, with a focus on Black men.
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Mapping protein shapes to improve cancer treatments
Researchers are using advanced computer models and lab imaging to map 3D protein shapes linked to cancer so future therapies can be better targeted for people with cancer.
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Folic acid and colon cancer risk in ulcerative colitis
This research looks at whether taking folic acid changes colon cancer risk for people with ulcerative colitis, especially when certain cell changes are present.
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Positive activities to help Asian American cancer patients and caregivers
This project will teach short positive activities to Asian American adults recently diagnosed with cancer to help reduce distress and feelings of being a burden on caregivers.
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Stopping fibroblasts from feeding pancreatic cancer by targeting ANO6
Researchers will try blocking a protein called ANO6 to stop nearby fibroblasts from delivering lipids to pancreatic cancer cells and help immunotherapy work better for people with pancreatic cancer.
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Blocking DNA polymerase theta in BRCA1-mutated cancers
This project is developing drugs that block DNA polymerase theta to try to kill tumors with BRCA1 mutations while sparing normal cells.
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MRCK enzymes and ovarian cancer spread
Researchers are trying to block MRCK enzymes to stop ovarian cancer cells from forming spheroids and spreading in people with recurrent ovarian cancer.
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Urine biomarker test to guide cystectomy decisions for bladder cancer
A urine test called NTACT could help doctors decide whether radical cystectomy is really needed for some bladder cancer patients.
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How liver damage and cell fitness drive beta‑catenin liver cancer
This work looks at how aging and chronic liver disease change the liver so cells with beta‑catenin mutations can grow into hepatocellular carcinoma, aiming to help people at risk for liver cancer.
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Blocking Wee1 to treat gastrointestinal stromal tumors
This project sees if adding a drug that blocks Wee1 to existing KIT/PDGFRA-targeting medicines helps people with gastrointestinal stromal tumors (GIST), especially when tumors stop responding to current treatments.
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Thyroid hormone (T3) as a treatment for childhood medulloblastoma
This work will see whether the thyroid hormone T3 can slow medulloblastoma growth and be used safely for children with this brain tumor.
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