Administrative Core support for a genome-wide study on T cell development
Official title: Administrative Core
Funded at Research Inst of Fox Chase Can Ctr · NIH-11395227 · Data updated 2026-11-12
A core grant supports coordinating a multi-site program using genome-wide and single-cell methods to study how T cell signals influence development and how mouse findings relate to human gamma-delta T cells.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2014 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $335,390 |
| NIH project number | 5P01AI102853-12 |
| Project ID | NIH-11395227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation in this core; findings may inform future patient-focused research.
✕Less likely to help
Direct patient participation is not a feature of this core grant.
What this research studies
This grant funds administrative coordination across four projects and a Genomics Core to manage a large, multi-site research effort. The work uses genome-wide and single-cell analyses to understand how TCR signal strength guides thymic progenitors toward gamma-delta fate and how mouse findings map to human gamma-delta development. It focuses on identifying regulatory elements and transcription factors that control lineage decisions. The Genomics Core will help map regulatory landscapes and assess activity across the genome. The Administrative Core ensures collaboration and data integration across sites and projects.
Why it matters
Potential benefit: If successful, the work could improve understanding of T cell development and inform future therapies that harness gamma-delta T cells.
How similar studies have gone: Previous genome-wide studies of T cell development provided foundational insights; this project builds a broader, cross-species view.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Wiest, David L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Wiest, David L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.