Linking TCR signal strength to Id3 dynamics in developing T cells
Official title: Linking TCR signal strength to Id3 transcriptional dynamics and nuclear positioning
Funded at Research Inst of Fox Chase Can Ctr · NIH-11395255 · Data updated 2026-11-12
This grant explores how different strengths of T cell receptor signals shape the development of two T cell lineages by studying Id3 transcription and its effect on gene regulation.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2014 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $468,843 |
| NIH project number | 5P01AI102853-12 |
| Project ID | NIH-11395255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with immune system disorders or those receiving T cell–focused therapies may indirectly benefit from insights into T cell development.
✕Less likely to help
Healthy individuals without immune-related conditions may not directly benefit.
What this research studies
Researchers will study how weak versus strong TCR signals direct developing T cells toward αβ or γδ lineages by mapping Id3 transcription dynamics and its impact on E protein function. They will use innovative methods to monitor mRNA synthesis in live primary lymphoid cells, focusing on bone marrow–derived cells to understand lineage decisions. The study integrates signaling pathways with transcriptional bursts to uncover how Id3 gradients influence cell fate. Findings could reveal fundamental rules of T cell development and identify potential points for intervention in immune disorders.
Why it matters
Potential benefit: Better understanding of T cell development could inform therapies for immune deficiencies and improve strategies for immune-based interventions.
How similar studies have gone: Previous work demonstrated that signaling strength affects T cell fate and transcriptional dynamics, with this project extending those findings to live-cell mRNA monitoring.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Murre, Cornelis — Research Inst of Fox Chase Can Ctr
- Study coordinator: Murre, Cornelis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.