E protein targets shaping early γδ T cell development and function
Official title: E protein targets orchestrating γδ development and function
Funded at Research Inst of Fox Chase Can Ctr · NIH-11395237 · Data updated 2026-11-12
A scientist-led project will explore how specific proteins control the development and function of a special type of immune cells called γδ T cells, which are important for keeping us healthy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2014 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $666,193 |
| NIH project number | 5P01AI102853-12 |
| Project ID | NIH-11395237 on NIH RePORTER |
Who could benefit from this research
✓Could help
This study is a basic science project using immune cells; patients with immune issues may benefit from long-term insights, but there is no direct patient participation required.
✕Less likely to help
No direct patient intervention or enrollment is involved in this grant.
What this research studies
This grant investigates how γδ T cells decide their fate in the thymus and how signaling differences guide their roles in immunity. Researchers will examine how E proteins and TCR signals reshape gene regulation to influence γδ T cell development and their ability to produce IL-17. The work uses genome-wide approaches to identify targets and pathways that govern these processes, with the aim of clarifying fundamental immune biology. Findings could inform strategies to manipulate γδ T cells in infections or immune disorders.
Why it matters
Potential benefit: Advances in understanding γδ T cell development could lead to new approaches for boosting immune defense or treating immune-related diseases.
How similar studies have gone: Previous work has shown that TCR signaling strength influences T cell fate via E proteins, with emerging but still developing connections to γδ T cell outcomes.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Wiest, David L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Wiest, David L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.