Intercepting pancreatic cancer by targeting a tumor-supporting network
Official title: Neutralizing Stromal NetrinG1 to Intercept Pancreatic Cancer
Funded at Research Inst of Fox Chase Can Ctr · NIH-11415069 · Data updated 2026-11-12
A patient-facing overview of a funded project that aims to stop pancreatic cancer from progressing by targeting the supportive tissue around tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $378,410 |
| NIH project number | 5U54CA272686-05 |
| Project ID | NIH-11415069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at high risk for pancreatic cancer, including those with hereditary risk, pancreatitis, or new-onset diabetes, may be eligible for related future trials or studies.
✕Less likely to help
People without the specific high-risk profiles or without progression toward precancerous tissue may not benefit from this particular approach.
What this research studies
This program focuses on preventing pancreatic cancer from advancing by interrupting the tumor's surrounding stroma. Researchers are studying a protein network in the tumor microenvironment and testing antibodies that may block cancer-supporting signals. The work involves collaboration within a specialized program to identify and screen potential agents that could intercept precancerous tissue before it becomes full-blown cancer. If successful, this approach could pave the way for earlier interventions for people at high risk for pancreatic cancer.
Why it matters
Potential benefit: If successful, the research could lead to earlier detection or interception strategies that slow or stop pancreatic cancer before it develops.
How similar studies have gone: Previous work has shown the tumor microenvironment influences pancreatic cancer progression, with some strategies moving toward interception, though this exact stroma-targeting approach is novel.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Cukierman, Edna — Research Inst of Fox Chase Can Ctr
- Study coordinator: Cukierman, Edna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.