SUMO regulation of ribosome production in human cells
Official title: SUMOylation regulation of ribosome biogenesis
Funded at Oregon Health & Science University · NIH-11528513 · Data updated 2026-11-12
A physician-facing project exploring how a chemical modification system called SUMO helps build ribosomes in human cells, which are essential for growth and health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $42,010 |
| NIH project number | 3R35GM153360-03S1 |
| Project ID | NIH-11528513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with ribosomopathies or related disorders where ribosome biogenesis is affected and who could benefit from future targeted therapies.
✕Less likely to help
Healthy individuals without ribosome biogenesis disorders may not directly benefit from this research.
What this research studies
This research looks at how ribosome production in healthy cells is controlled by SUMO signaling and how this control goes awry in disease. The team studies key proteins like USP36 and SENP3 that add and remove SUMO marks to ribosome-processing components, affecting how ribosomes are made. By mapping these processes, the project aims to reveal new targets that could be relevant for ribosomopathies and related disorders. The work combines experiments in cell biology to understand the timing and localization of SUMO modifications in the nucleolus. The findings could pave the way for future therapies that correct ribosome production defects at the cellular level.
Why it matters
Potential benefit: If successful, the project could identify new molecular targets to treat diseases caused by ribosome production problems.
How similar studies have gone: Previous work has shown SUMO dynamics influence ribosome assembly, suggesting potential for impactful discoveries with this approach.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Dai, Mu-Shui — Oregon Health & Science University
- Study coordinator: Dai, Mu-Shui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.