Sponsor or institution
Clinical trials and research at Loyola University Chicago
As of November 12, 2026, Find a Trial lists 111 NIH-funded research projects at this institution, with $49.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 111NIH research projects
NIH-funded research (newest 40 of 111)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Identifying key cells and genes in children with MODS on ECMO
A high-tech study using single-cell analyses to find the important cells and genes that drive organ failure in critically ill children on ECMO support.
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Preventing childhood B-ALL through maternal diet and TVA intake
A study at Loyola University Chicago will explore whether a mother’s intake of TVA during pregnancy can help prevent childhood B-ALL in babies.
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Prenyltransferase inhibitor as a new therapy for inflammatory neuropathy
A new drug candidate called FGTI-2734 is being studied to calm nerve inflammation in conditions like AIDP/Guillain-Barré syndrome, with the goal of protecting nerves and reducing symptoms.
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Leading causes of death in alcoholic ARDS patients using clinical data
This project uses big clinical data and AI to find the main factors that cause death in adults with ARDS who have alcohol use issues, aiming to improve understanding and care.
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Affinity maturation in lung immune tissues in autoimmune disease
Aims to understand how immune cells in the lungs of people with autoimmune or allergic conditions refine their antibodies right where exposure happens.
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Understanding how secreted messengers cause systemic inflammation in humans
A small NIH grant will study which secreted proteins drive systemic inflammation in living bodies, with a focus on conditions like sepsis and autoimmune diseases.
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Understanding how a non-traditional ISG15 helps or hinders flu virus control
A small NIH-funded project will explore how a specific human immune gene, ISG15, and its different forms affect influenza virus infection in cells.
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RNA splicing changes in alcohol withdrawal and brain function
A scientist at Loyola University Chicago is studying how quitting alcohol changes brain gene messaging, especially RNA splicing, to see why withdrawal can worsen mood and drinking urges.
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Integrated treatment for people with both opioid and alcohol use disorders using GLP-1 medicines and standard therapies
A real-world study of how combining GLP-1 receptor agonists with usual opioid and alcohol treatments works for people who have both disorders.
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Multisensory Early Oral Human Milk for Very Preterm Infants
A randomized trial tests giving tiny drops of human milk in a multisensory way to very preterm babies starting on day 3 to support stress regulation, brain development, and easier oral feeding.
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Atrial heart proteins and how they control heartbeats
A research grant explores how specific atrial heart proteins control atrial contraction and may influence arrhythmias and cardiomyopathy in humans.
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Pathways in the brain that drive dependence on alcohol linked to a specific receptor
This grant studies how a brain receptor system involved in learning and memory may drive stronger, harder-to-change alcohol use in people with alcohol dependence.
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Weighting real-world data to understand opioid tapering outcomes in people with chronic pain and substance use disorders
A real-world study will create and test statistical weights to better understand how tapering opioids works for patients who have chronic pain and substance use disorders.
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Fitbit monitoring to spot infections early after children's surgery
This project uses a Fitbit to track activity, heart rate, and sleep in children after surgery to help spot infections sooner and reduce unneeded emergency visits.
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Polyamines and viral infection: how viruses hijack cell metabolism
This grant explores how RNA viruses use cellular polyamines to enter cells, replicate, and affect cell metabolism, with the goal of finding ways to block infection.
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Burn injury sepsis: finding early immune clues and blocking harmful signals to save lives
A patient-focused research effort to understand why severe burns lead to dangerous infections and sepsis and test ways to prevent it by studying the body's early immune shifts and a signaling pathway.
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Mechanosensing LIM Domains and How Cells Feel Force
Scientists are studying how cells turn physical forces into signals, by looking at LIM domain proteins that sense strain in actin fibers to help cells respond and repair themselves.
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Understanding how adolescent binge drinking changes brain chemistry
This project looks at how heavy drinking during teen years alters brain cells and could lead to lasting problems, with a focus on the stress response system.
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Development of B cell memory in allergic asthma
A study in a mouse model looks at how memory B cells and IgE antibodies develop in allergic asthma to identify targets that could reduce or prevent allergic flares.
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Understanding how uterine natural killer cells develop and respond to hormones
A short research grant is exploring how specific immune cells in the uterus form and behave, with a focus on how hormones like progesterone influence them.
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How cells control their internal motors to shape tissues
This NIH grant funds research to understand how cells tune their internal motors (myosin 2) to generate the right amount of force in the right place, helping tissues develop and stay healthy.
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Opioid tapering outcomes for people with chronic pain and substance use disorder
Using medical records from many hospitals, this project looks at what happens when opioids are reduced for people who have chronic pain and also a substance use disorder.
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How the Heart Controls Calcium for Health and Heart Failure
Scientists are studying how calcium-handling proteins in the heart work normally and what goes wrong in heart failure, with the aim of finding new ways to treat it.
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AI-powered dosing helper for vancomycin in ICU patients
A lightweight AI-assisted tool helps doctors estimate the right vancomycin dose for ICU patients to keep drug levels safe and effective.
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Why older adults with glioblastoma have worse outcomes
This project looks at biological differences outside the tumor that may explain why people aged 65 and older with IDH-wildtype glioblastoma have poorer survival after standard treatment.
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How Pseudomonas bacteria disable the cornea's cell defenses
This project looks at how Pseudomonas bacteria hide inside corneal cells and shut down local defenses, which could help people with contact lens–related eye infections.
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ABL2 and alcohol-related liver damage
This project is seeing if blocking a protein called ABL2 can prevent or reduce liver damage in people with alcohol-associated liver disease.
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How macrophages detect danger signals and calcium
Researchers are building computer models to show how macrophages (a type of immune cell) react to ATP and calcium, which can drive inflammation in conditions like cancer and sepsis.
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Keeping heart muscle proteins healthy in heart failure
This project looks at whether boosting a protein called BAG3 can help heart muscle proteins stay healthy and improve heart function for people with heart failure.
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Stopping harmful PANoptosis to help people with myelodysplastic syndromes
Researchers aim to block a form of inflammatory cell death called PANoptosis to try to improve blood counts and reduce disease progression in people with myelodysplastic syndromes (MDS).
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Improving drugs that target the Y537S estrogen receptor in breast cancer
Looks at how different anti-hormone drugs change the Y537S estrogen receptor mutation in ER-positive breast cancer to help find better treatments.
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Race-based stress reduction to improve well-being and inflammation in older African American women at risk for cardiometabolic disease
A group-based 8-week program helps older African American women who are at risk for cardiometabolic disease manage stress from racism and sexism to improve well-being and reduce inflammation.
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Family-based self-management support for youth with spina bifida
A patient-facing program designed to help children with spina bifida and their caregivers manage daily health tasks at home.
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How heart attacks and oxidative stress damage the heart's calcium release channel
Researchers will see if specific chemical bonds form between parts of the heart's calcium release channel during oxidative damage from a heart attack and cause calcium imbalance that leads to poor heart contractions and arrhythmias.
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Using RNA changes to reduce sex-based thinking and memory problems
This work looks at whether fixing a specific RNA edit can ease thinking, memory, and social problems that differ between males and females, with relevance to autism.
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Improving tribal opioid data and culturally tailored medications for American Indian and Alaska Native communities
This project will build better tribe-level opioid overdose data and work with American Indian and Alaska Native communities to adapt medications for opioid use disorder so they fit local cultural needs.
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How the heart enzyme PDE1 controls calcium and heart pumping
Looking at whether blocking the heart enzyme PDE1 can safely improve heart muscle calcium handling and strengthen heartbeats in adults with weakened hearts.
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A vaccine to protect adults from future pandemic coronaviruses
This project develops a vaccine to train adults' immune systems to better protect against future pandemic coronaviruses.
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How estrogen affects tiny gene regulators (microRNAs) in Alzheimer's, especially in women
This work looks at how the hormone estrogen changes tiny gene regulators called microRNAs in the aging brain and in people with Alzheimer's to help explain why women are more affected.
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How alcohol-related burns change gut bacteria and damage the intestinal lining
This project looks at whether burns that happen while someone is intoxicated change gut bacteria and weaken the intestine, which may lead to worse recovery.
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