Development of B cell memory in allergic asthma
Funded at Loyola University Chicago · NIH-11376638 · Data updated 2026-11-12
A study in a mouse model looks at how memory B cells and IgE antibodies develop in allergic asthma to identify targets that could reduce or prevent allergic flares.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | June 15, 2022 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $609,645 |
| NIH project number | 2R01HL165120-05 |
| Project ID | NIH-11376638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with allergic asthma or related airway inflammatory conditions who may benefit from therapies targeting B cell memory and IgE pathways in the future.
✕Less likely to help
Patients without allergic asthma or those not involved in future translational steps may not directly benefit.
What this research studies
This project uses a mouse model of allergic lung inflammation to explore how allergen exposure leads to lung-resident memory B cells and persistent IgE responses. Researchers will map the signals that bring B cells into inflamed lungs and how lung stromal cells support these B cells over the long term. By understanding where and how these memory cells form and survive, the study aims to identify new points to intervene and reduce allergic reactions in the airways. The findings could inform future therapies aimed at preventing recurrent asthma attacks driven by IgE.
Why it matters
Potential benefit: If successful, the work could point to new strategies to lessen or prevent allergic asthma flares by targeting lung memory B cells and IgE production.
How similar studies have gone: Previous work has shown a role for memory B cells and IgE in allergic responses, with ongoing translational efforts shaping new therapeutic approaches.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Wu, Yee Ling — Loyola University Chicago
- Study coordinator: Wu, Yee Ling
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.