Identifying key cells and genes in children with MODS on ECMO
Official title: Single cell multi-omics approaches in identifying driving cells and genes in pediatric MODS patients requiring ECMO support
Funded at Loyola University Chicago · NIH-11538903 · Data updated 2026-11-12
A high-tech study using single-cell analyses to find the important cells and genes that drive organ failure in critically ill children on ECMO support.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $248,999 |
| NIH project number | 4R00HD111575-03 |
| Project ID | NIH-11538903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are pediatric patients with MODS who require or are anticipated to require ECMO support in an ICU setting.
✕Less likely to help
Patients not at risk for MODS progression on ECMO or not receiving ECMO support may not directly benefit.
What this research studies
This project aims to uncover cellular and molecular drivers of MODS deterioration in pediatric patients requiring advanced life support. By applying single-cell multi-omics and machine learning, the researchers plan to map immune responses and epigenetic changes at a granular level. The goal is to develop new biomarkers and therapeutic strategies that could help clinicians diagnose deterioration earlier and tailor treatments in the ICU. The work builds on prior findings from larger datasets and focuses specifically on children with MODS on ECMO.
Why it matters
Potential benefit: If successful, the study could lead to earlier detection of MODS worsening and personalized treatment approaches for critically ill children on ECMO.
How similar studies have gone: Previous bulk analyses suggested immune and epigenetic factors in MODS; this study adds single-cell detail and could confirm or refine those findings.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Shankar, Rama — Loyola University Chicago
- Study coordinator: Shankar, Rama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.