Sponsor or institution
Clinical trials and research at Dartmouth-Hitchcock Clinic
As of November 12, 2026, Find a Trial lists 102 NIH-funded research projects at this institution, with $57.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 102NIH research projects
NIH-funded research (newest 40 of 102)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Certified Older Adult Peer Support Telephonic Help for Independent Living with Serious Mental Illness
A phone-based program uses trained peer support specialists aged 50+ to help older adults with serious mental illness living at home maintain independence.
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BEDRoC Core supports aging with serious illness research at CASI
A core service hub helps researchers study aging with serious illness by offering statistics, ethics guidance, data management, research design, and community engagement.
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Improving heart and leg health care in rural communities with GDMT and guided exercise
A rural-focused program aims to help people with intermittent claudication from peripheral artery disease get better with guideline-based medicines and a structured exercise plan.
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Reducing Colorectal Cancer Through Big Data and Modeling
A large project uses decades of colonoscopy data and advanced modeling to reduce how often people develop colorectal cancer and improve screening quality.
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How the gut bacterium Akkermansia helps control intestinal inflammation
Researchers are looking at how the common gut microbe Akkermansia uses surface proteins to live on the intestinal lining and reduce inflammation in people with conditions like type 2 diabetes.
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Spine Laser Therapy to Treat Metastases
Aims to use a minimally invasive laser therapy to treat spinal metastases and reduce pain, recovery time, and disruption to other cancer treatments.
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Bile acids shaping gut immunity with friendly bacteria
This project looks at how bile acids and gut bacteria interact to influence immunity in the gut.
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Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
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Long‑lasting environmental poisons in veterans' brains tied to higher ALS risk
This project looks for persistent toxic chemicals in veterans' brain and spinal cord tissue that might explain why veterans develop ALS more often.
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Risk-Benefit Decisions for Metoidioplasty and Phalloplasty
A patient-friendly project is testing a web-based decision aid to help people considering metoidioplasty or phalloplasty understand options, risks, and outcomes to make informed choices.
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Pediatric Clinical Trials Unit at Dartmouth: expanding access to child-focused trials
A dedicated pediatric Clinical Trials Unit at Dartmouth helps doctors run and connect child-focused trials, including kids from rural areas, to improve breathing and overall health.
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Deep Learning to Improve Interpretation of Intrapartum Fetal Monitoring
A data-driven AI approach is being developed to help clinicians interpret fetal monitoring during labor to improve decisions in delivery care.
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Adjuvant Photodynamic Therapy to Reduce Infections in High-Energy Open Fractures
Aims to test a light-activated treatment added to standard care to lower bacterial load and prevent infections after serious open bone injuries.
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Neural rhythm markers to tailor mental health care in a rat model
A study in rats tests whether brain wave patterns can predict how different interventions will affect behavior, with the goal of guiding personalized mental health treatments in people.
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Sustaining proven mental health lifestyle programs to cut heart risks
A long-term study to keep a proven lifestyle program (InSHAPE) helping adults with serious mental illness reduce heart disease risk while staying active in real-world mental health settings.
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Investigating environmental metals and nanoparticles linked to ALS in Massachusetts patients
A study looks at how toxic elements and nanoparticles may contribute to ALS in patients from Massachusetts to better understand disease causes.
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Melanocyte PD-L1 and UVB-triggered IFN-I in melanoma
A study in mice explores how PD-L1 on melanocytes and UVB exposure affect immune signals and melanoma growth, to inform future therapies.
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Bladder cancer: how PD-L1 inside cells affects BRCA1 repair and new treatments
A cancer research project at Dartmouth-Hitchcock Clinic is exploring how bladder cancer’s internal PD-L1 signals change BRCA1’s DNA repair work to influence response to PARP inhibitors and immune therapies.
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Bile acids and the gut immune system
A study in mice looks at how bile acids influence intestinal immune responses and how gut bacteria, liver, and gut cells talk to each other to shape these signals.
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Rural Health Translational Science Innovation at Dartmouth
This grant supports a national effort to speed up practical health improvements for people in rural areas by strengthening collaboration, using telehealth and digital tools, and developing ways to translate research into real-world care.
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Identifying Environmental Exposures Linked to ALS Risk in Veterans
This grant looks at why US veterans have a higher risk of ALS by studying lasting environmental toxicants in veterans’ CNS tissue.
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Bringing clear health information to PACS patients and providers in rural New England
A project to create easy-to-understand health information about post-acute COVID syndrome for patients and clinicians in rural northern New England.
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Interactive visual aid to support stopping cancer treatment decisions in advanced cancer
A mentored clinician-researcher will develop and test an interactive visual tool to help patients with advanced cancer, their caregivers, and clinicians communicate about stopping treatment in a way that respects patient values and reduces uncertainty.
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Real-time bone perfusion imaging to guide cleaning out infected bone
A real-time imaging tool helps surgeons remove only the infected, poorly perfused bone during treatment of infections after fractures, aiming to improve healing and reduce the need for repeat surgeries.
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Geospatial drivers of cancer care gaps and policy effects
A researcher at Dartmouth-Hitchcock is studying how where people live and their finances affect cancer care and how health policy changes may change access and outcomes.
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Understanding spinal cord circuits behind chronic pain in adults
A study in adults with pain will look at how specific spinal neurons may change from acute to chronic pain and how nerve injury affects their signaling.
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Comparative-Effectiveness of Carotid Revascularization Procedures
This grant explores how well different carotid artery procedures work to lower stroke risk for people with narrowed carotid arteries.
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E-cigarettes plus optional counseling to help adults with mental illness switch from cigarettes
This project offers e-cigarettes, with or without behavioral support, to adults with mental illness who smoke to help them switch away from cigarettes.
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Why lung inflammation stays active in cystic fibrosis
This research looks at immune cells in people with cystic fibrosis to understand why lung inflammation keeps going even after CFTR medicines.
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Changing the tumor environment to prevent relapse and lung spread in triple negative breast cancer
This project gives a long‑term copper‑lowering medicine called tetrathiomolybdate to people with high‑risk triple negative breast cancer alongside standard chemotherapy and immunotherapy to help stop cancer from coming back.
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National Clinical Trials Network: Lead Academic Participating Site at Dartmouth Cancer Center
A major cancer center in northern New England will continue coordinating and leading nationwide clinical trials to bring cutting-edge treatments to patients in Vermont, New Hampshire, and surrounding rural areas.
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COPD in rural areas: how air and home exposures affect health
This grant explores how outdoor and indoor air pollution, including solid fuel use for heating, influence COPD outcomes among people living in rural US communities.
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Measuring low-value pediatric hospital care and how urban and rural settings differ
Aims to identify which common pediatric hospital practices provide little benefit and may cause harm or extra costs, and how these practices vary between urban and rural hospitals.
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Unequal access to remote monitoring for rural heart device patients
This grant plans to study how people in rural areas with pacemakers or defibrillators may have worse outcomes due to connectivity and access gaps, and how remote monitoring could help.
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Community Engagement & Outreach Core for rural health research
A core team at a rural health center helps researchers and community members work together to improve healthcare delivery in northern New England.
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Statistics and Informatics Core to Improve Rural Health Care Delivery
A core program at a major clinic is building better ways to analyze data from rural health care to improve how care is delivered.
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Administrative & Mentoring Core supports rural health care delivery research
A funding opportunity to strengthen leadership, mentorship, and administration for a center focused on improving rural health care delivery.
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Center for Rural Health Care Delivery Science at a rural academic medical center
A national center aims to improve how health care is delivered in rural areas by training clinician-scientists and studying rural health care challenges.
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How long-lived immune cells on the eye surface affect inflammation and pain
This research looks at whether long-lived immune cells that live on the eye's surface cause inflammation and chronic pain in people with dry eye and other front-of-eye conditions.
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Improving health outcomes for older adults with osteoarthritis and multiple health conditions
Aimed at helping adults over 21 with osteoarthritis and other chronic health issues improve how they feel and function through better activity, weight management, and overall care.
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