Reducing Colorectal Cancer Through Big Data and Modeling
Official title: Decreasing colorectal cancer: Using longitudinal population-based evidence and modeling to investigate key issues that can reduce colorectal cancer
Funded at Dartmouth-Hitchcock Clinic · NIH-11465419 · Data updated 2026-11-12
A large project uses decades of colonoscopy data and advanced modeling to reduce how often people develop colorectal cancer and improve screening quality.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $733,688 |
| NIH project number | 1R01CA310053-01A1 |
| Project ID | NIH-11465419 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older who are part of or contribute data to colonoscopy registries, especially those under 50 for early-onset CRC analysis.
✕Less likely to help
Patients not contributing data to registries or not impacted by revised screening recommendations may see limited direct benefit.
What this research studies
This project will analyze long-term data from the NHCR and use CISNET’s modeling to identify gaps in screening and follow-up that can prevent colorectal cancer. Researchers will examine incidence, especially Early-Onset CRC in adults under 50, and how colonoscopy quality affects prevention. The study combines real-world clinical data with sophisticated simulations to inform better screening guidelines and quality metrics. Participants would not be required unless they contribute data to the NHCR, and the work is aimed at improving population-level prevention strategies.
Why it matters
Potential benefit: If successful, the work could lead to better screening practices and fewer colorectal cancer deaths.
How similar studies have gone: Previous CISNET-informed screening policies have helped optimize prevention strategies in the U.S.
Where this research is happening
-
Dartmouth-Hitchcock Clinic
Lebanon, United States Active
Researchers
- Principal investigator: Butterly, Lynn F — Dartmouth-Hitchcock Clinic
- Study coordinator: Butterly, Lynn F
Related research
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Comparative modeling to guide colorectal cancer screening and care
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.