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Clinical trials and research at Alliance for Clinical Trials in Oncology

• 26Clinical trials
• 4Countries

Newest trials

All recruiting trials (26)

• Adding a targeted cancer drug to standard therapy for untreated CLL/SLL

  This trial tests whether adding sonrotoclax to zanubrutinib helps people with untreated CLL/SLL live longer without the disease getting worse.

  Recruiting at 259 sites Phase 3 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 260 other locations · NCT07321652

• Targeted post-surgery radiation plus standard therapy for NSCLC with remaining nodal cancer

  This phase II trial tests whether adding intensity-modulated post-operative radiation therapy to standard chemotherapy or immunotherapy helps people with non-small cell lung cancer and remaining lymph node cancer after surgery.

  Recruiting at 121 sites Phase 2 Alliance for Clinical Trials in Oncology · Jonesboro, Arkansas and 124 other locations · NCT07293247

• Using the PAGODA algorithm to guide FOLFOX dose changes and reduce unplanned chemotherapy delays

  This trial will test whether using the PAGODA algorithm to guide dose changes during FOLFOX chemotherapy for people with gastrointestinal cancers can reduce unplanned treatment delays.

  Recruiting at 391 sites Alliance for Clinical Trials in Oncology · Fairbanks, Alaska and 397 other locations · NCT07283939

• Vor a sid en ib + temozolomide after radiation for IDH-mutant astrocytoma (grade 3)

  This phase 3 trial tests whether adding vorasidenib to the usual temozolomide after radiation helps people with newly diagnosed IDH-mutant astrocytoma (grade 3).

  Recruiting at 176 sites Phase 3 Alliance for Clinical Trials in Oncology · Phoenix, Arizona and 176 other locations · NCT07215910

• Testing Different Dosing Schedules of Lutetium-177Lu PSMA RLT in Advanced Prostate Cancer

  This trial tests if spacing out Lutetium-177Lu PSMA RLT doses adapts to the patient and improves quality of life without shortening life in men with advanced, hormone-resistant prostate cancer.

  Recruiting at 105 sites Phase 3 Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 141 other locations · NCT07200830

• Family genetics: who shares test results with relatives

  This study tests whether letting patients share genetic results with their relatives is as good as doctors sharing the results to help first-degree relatives get genetic testing for hereditary cancer risk.

  Recruiting at 362 sites Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 364 other locations · NCT07143487

• Digital chatbot program for inherited cancer genetic testing in young adults

  This study tests whether a chatbot-based digital program helps young adults with cancer (ages 18–39) get genetic counseling and testing more often than standard remote genetic services.

  Recruiting at 323 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 326 other locations · NCT07091617

• Virtual exercise program to preserve function and prevent disability during chemotherapy

  This trial tests whether supervised resistance sessions by video plus short home aerobic workouts help adults 18–64 maintain strength and stay active while receiving curative-intent chemotherapy.

  Recruiting at 29 sites Alliance for Clinical Trials in Oncology · Dublin, California and 29 other locations · NCT07059884

• Adding gemcitabine to BCG for people with recurrent non‑muscle invasive bladder cancer.

  This phase III test tries whether giving intravesical gemcitabine alongside BCG helps people whose non‑muscle invasive bladder cancer has come back after prior BCG.

  Recruiting at 60 sites Phase 3 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 59 other locations · NCT07000084

• High-dose gabapentin versus placebo to prevent opioid use for mouth pain during chemoradiation for head and neck cancer

  This will test whether taking high-dose gabapentin during cisplatin chemoradiation for head and neck cancer helps people avoid needing opioid pain medicine for painful mouth sores.

  Recruiting at 191 sites Phase 3 Alliance for Clinical Trials in Oncology · Gilbert, Arizona and 215 other locations · NCT06992427

• Adding docetaxel to hormonal therapy and apalutamide for metastatic prostate cancer

  This trial tests whether giving the chemotherapy drug docetaxel in addition to hormone therapy and apalutamide helps men with metastatic castration-sensitive prostate cancer live longer.

  Recruiting at 208 sites Phase 3 Alliance for Clinical Trials in Oncology · Tucson, Arizona and 213 other locations · NCT06931340

• 6 months versus 12 months of HER2-targeted therapy after a complete response to preoperative chemo for early HER2+ breast cancer

  This tests whether 6 months of HER2-targeted therapy works as well as 12 months for people with early HER2+ breast cancer who had a pathologic complete response after preoperative chemotherapy with trastuzumab.

  Recruiting at 604 sites Phase 3 Alliance for Clinical Trials in Oncology · Phoenix, Arizona and 701 other locations · NCT06876714

• Combining Tivozanib with Pembrolizumab for Kidney Cancer Treatment

  This study is testing if adding a cancer drug called tivozanib to the immunotherapy pembrolizumab can help people with high-risk kidney cancer live longer and feel better after their surgery.

  Recruiting at 409 sites Phase 3 Alliance for Clinical Trials in Oncology · Phoenix, Arizona and 428 other locations · NCT06661720

• Targeted treatment for advanced prostate cancer

  This study is testing whether using genetic testing to guide treatment can help people with advanced prostate cancer respond better to new medications.

  Recruiting at 98 sites Phase 2 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 107 other locations · NCT06632977

• Comparing continuous and intermittent treatment with zanubrutinib for older patients with mantle cell lymphoma

  This study tests whether older patients with mantle cell lymphoma do better with continuous or intermittent treatment using zanubrutinib after they have achieved complete remission with rituximab.

  Recruiting at 233 sites Phase 3 Alliance for Clinical Trials in Oncology · Little Rock, Arkansas and 241 other locations · NCT05976763

• Comparing pembrolizumab to observation for early-stage triple-negative breast cancer after chemotherapy

  This study tests whether a drug called pembrolizumab can help prevent the return of early-stage triple-negative breast cancer after chemotherapy, compared to just keeping an eye on patients without extra treatment.

  Recruiting at 797 sites Phase 3 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 845 other locations · NCT05812807

• Comparing two chemotherapy regimens for advanced HER2 negative gastric and esophageal cancer

  This study is testing if a new chemotherapy combination can help people with advanced HER2 negative stomach and esophageal cancer live longer compared to the standard treatment.

  Recruiting at 626 sites Phase 3 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 801 other locations · NCT05677490

• Combining total ablative therapy with standard treatment for limited metastatic colorectal cancer

  This study is testing if adding a special type of radiation therapy and possible surgery to standard chemotherapy can help people with limited metastatic colorectal cancer live longer and stay healthier.

  Recruiting at 172 sites Phase 2 Alliance for Clinical Trials in Oncology · Kingman, Arizona and 194 other locations · NCT05673148

• Immunotherapy before surgery for sarcomatoid mesothelioma

  This study is testing if giving immunotherapy before surgery can help patients with stage I-IIIa sarcomatoid mesothelioma be able to have surgery and stay cancer-free for longer.

  Recruiting at 104 sites Phase 2 Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 131 other locations · NCT05647265

• Vaginal CO2 laser for vaginal dryness in breast cancer survivors

  This trial will test whether a vaginal fractional CO2 laser can reduce vaginal dryness in women who have finished breast cancer treatment.

  Recruiting at 2 sites Phase 3 Alliance for Clinical Trials in Oncology · Des Moines, Iowa and 2 other locations · NCT05379153

• Collecting blood samples to evaluate tests for early cancer detection

  This study is collecting blood and tissue samples from people with and without cancer to see if new tests can help detect cancer earlier.

  Recruiting at 619 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 750 other locations · NCT05334069

• Text-based program to help rural cancer survivors quit smoking

  This study is testing whether a text message program can help rural cancer survivors quit smoking better than a printed booklet.

  Recruiting at 205 sites Phase 3 Alliance for Clinical Trials in Oncology · Kingman, Arizona and 223 other locations · NCT05008848

• Testing new treatments for peripheral T-cell lymphoma

  This study is testing whether adding new drugs, duvelisib or CC-486, to standard chemotherapy can help people with peripheral T-cell lymphoma achieve better treatment results.

  Recruiting at 84 sites Phase 2 Alliance for Clinical Trials in Oncology · Little Rock, Arkansas and 95 other locations · NCT04803201

• Collecting data and samples from patients with immunotherapy side effects

  This study is collecting blood, tissue, and stool samples from patients who have serious side effects from immunotherapy to help understand and improve how to manage these reactions.

  Recruiting at 394 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 629 other locations · NCT04242095

• Inotuzumab ozogamicin with frontline chemotherapy for young adults with B‑cell acute lymphoblastic leukemia

  This trial tests whether adding the antibody-drug inotuzumab ozogamicin to a pediatric-style frontline chemotherapy plan helps young adults with newly diagnosed CD22-positive B acute lymphoblastic leukemia live longer without relapse.

  Recruiting at 157 sites Phase 3 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 459 other locations · NCT03150693

• Treating progressive meningiomas with targeted therapies

  This study is testing if new targeted therapies can help people with progressive meningiomas who have certain genetic mutations feel better and live longer.

  Recruiting at 478 sites Phase 2 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 790 other locations · NCT02523014

Quick answers

How many clinical trials run by Alliance for Clinical Trials in Oncology are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (26 trials), Puerto Rico (5 trials), Canada (3 trials), Guam (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 14, Phase 2: 6. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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