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Text-based program to help rural cancer survivors quit smoking

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Cessation Interventions

Phase 3 Interventional Alliance for Clinical Trials in Oncology · NCT05008848

This study is testing whether a text message program can help rural cancer survivors quit smoking better than a printed booklet.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment600 (estimated)
Ages18 Years and up
SexAll
SponsorAlliance for Clinical Trials in Oncology Academic / other
Locations220 sites (Kingman, Arizona and 219 other locations)
Trial IDNCT05008848 on ClinicalTrials.gov

What this trial studies

This phase III trial evaluates the effectiveness of an eight-week text-based scheduled gradual reduction (SGR) intervention designed to assist rural cancer survivors who smoke in quitting. Participants are randomized into two groups: one receiving personalized text messages to gradually reduce smoking and the other receiving a cessation booklet. The primary goal is to assess smoking cessation rates six months after quitting, while secondary objectives include evaluating the impact on overall quality of life. Follow-up assessments will occur at 30 days and six months post-quit date.

Who should consider this trial

Good fit: Ideal candidates are rural cancer survivors who smoke at least five cigarettes daily and are interested in quitting.

Not a fit: Patients currently using smoking cessation pharmacotherapy or participating in another cessation program may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve smoking cessation rates among rural cancer survivors, enhancing their overall health and quality of life.

How similar studies have performed: Other studies have shown promising results with text-based smoking cessation interventions, indicating potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Have a cancer diagnosis within the past 10 years, and can currently be receiving curative treatment
* Not currently on hospice
* Currently smokes \>= 5 cigarettes daily
* Lives in a nonmetro/rural county (defined as having a Rural Urban Continuum Code \[RUCC\] code of 4-9)
* Patient interested in participating in a smoking cessation program, and not currently participating in a smoking cessation clinical trial
* Not currently using any smoking cessation pharmacotherapy (e.g. nicotine replacement therapy, bupropion or varenicline), or currently participating in any cessation program
* Patient has a cell phone or smart phone device with texting ability
* In order to complete the mandatory patient-completed measures, participants must be able to speak and read English
* Age \>= 18 years
* Participant must be willing to provide a urine sample.

Exclusion Criteria:

* Psychiatric illness which would prevent the patient from giving informed consent
* Patients with impaired decision-making capacity are not eligible for this study.

Where this trial is running

Kingman, Arizona and 219 other locations

+170 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cigarette Smoking-Related Carcinoma
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.