Zip-stitch for laparoscopic hysterectomy
Official title: Zip-stitch for Laparoscopic Hysterectomy - Clinical Validation
Funded at Zsx Medical, LLC · NIH-11305976 · Data updated 2026-11-12
A new Zip-stitch wound-closure system is being tested in people to make vaginal cuff closure after laparoscopic hysterectomy faster, simpler, and safer.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Zsx Medical, LLC NIH-funded |
| Lab location | 1 site (Philadelphia, UNITED STATES) |
| Project start | September 22, 2021 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,000,000 |
| NIH project number | 5R44HD104539-04 |
| Project ID | NIH-11305976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults undergoing laparoscopic hysterectomy who require vaginal cuff closure.
✕Less likely to help
Patients not undergoing vaginal cuff repair or those with contraindications to bioabsorbable clips may not benefit.
What this research studies
This project tests a bioabsorbable clip system that helps surgeons close the vaginal cuff during laparoscopic hysterectomy. It uses an applicator to place clips that seal edges without piercing tissue and promote healing. The goal is to reduce technical difficulty, speed up the procedure, and lower the risk of wound opening after surgery. The work builds on earlier clinical results and aims to refine the device for broader clinical use and commercialization.
Why it matters
Potential benefit: If successful, patients could experience quicker surgeries, fewer cuff-related complications, and improved healing after hysterectomy.
How similar studies have gone: Previous clinical results were promising, supporting further development and validation of this device.
Where this research is happening
-
Zsx Medical, LLC
Philadelphia, United States Active
Researchers
- Principal investigator: Mazzucco, Dan C — Zsx Medical, LLC
- Study coordinator: Mazzucco, Dan C
Related research
Other NIH-funded projects on the same topics.
-
Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
-
A safe, fast, and lower-cost way to remove large uterus tissue during minimally invasive hysterectomy
A new device called the Claria System aims to remove large uteruses quickly and safely during minimally invasive hysterectomy and other surgeries, while reducing costs.
-
A safer, faster tissue removal system for laparoscopic hysterectomy
A new containment and extraction system for removing large uteri during laparoscopic hysterectomy is being tested to see if it’s safer and faster than current methods.
-
A safer, faster, and more affordable way to remove large uteri during minimally invasive surgery
A new surgical device to help surgeons remove large uteri quickly and safely during minimally invasive hysterectomy and similar operations, reducing the chance of spreading hidden cancer.
-
A new method for closing surgical wounds after laparoscopic hysterectomy
This study is testing a new way to close wounds after laparoscopic hysterectomy using a special system called Zip-stitch, which uses dissolvable clips to help you heal better and recover faster, with input from surgeons to make it even better for future use.
-
Creating tools to predict outcomes for Black women with endometrial cancer after surgery
This study is working to create helpful tools for doctors to better understand and treat Black women with endometrial cancer after surgery, aiming to improve their care and outcomes by considering their unique needs and risks.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.