A new method for closing surgical wounds after laparoscopic hysterectomy
Official title: Zip-stitch for Laparoscopic Hysterectomy - Clinical Validation
Funded at Zsx Medical, LLC · NIH-11068352 · Data updated 2026-11-12
This study is testing a new way to close wounds after laparoscopic hysterectomy using a special system called Zip-stitch, which uses dissolvable clips to help you heal better and recover faster, with input from surgeons to make it even better for future use.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Zsx Medical, LLC NIH-funded |
| Lab location | 1 site (Philadelphia, UNITED STATES) |
| Project start | September 22, 2021 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,000,000 |
| NIH project number | 2R44HD104539-03 |
| Project ID | NIH-11068352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women scheduled to undergo laparoscopic hysterectomy.
✕Less likely to help
Patients who are not undergoing laparoscopic hysterectomy or those with contraindications for this type of surgery may not benefit from this research.
What this research studies
This research focuses on the development and clinical validation of the Zip-stitch system, a novel surgical wound closure method specifically designed for laparoscopic hysterectomy. The system utilizes bioabsorbable clips that are applied to the vaginal cuff wound to enhance healing and reduce complications such as wound separation. By simplifying the suturing process, the Zip-stitch aims to improve surgical outcomes and patient recovery times. The research involves feedback from surgeons and aims to refine the system for future commercialization.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective surgical procedures for patients undergoing laparoscopic hysterectomy.
How similar studies have gone: Previous studies have shown promising results with similar surgical closure techniques, indicating potential for success with the Zip-stitch system.
Where this research is happening
-
Zsx Medical, LLC
Philadelphia, United States Active
Researchers
- Principal investigator: Mazzucco, Dan C — Zsx Medical, LLC
- Study coordinator: Mazzucco, Dan C
Related research
Other NIH-funded projects on the same topics.
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Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
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A safe, fast, and lower-cost way to remove large uterus tissue during minimally invasive hysterectomy
A new device called the Claria System aims to remove large uteruses quickly and safely during minimally invasive hysterectomy and other surgeries, while reducing costs.
-
A safer, faster tissue removal system for laparoscopic hysterectomy
A new containment and extraction system for removing large uteri during laparoscopic hysterectomy is being tested to see if it’s safer and faster than current methods.
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Zip-stitch for laparoscopic hysterectomy
A new Zip-stitch wound-closure system is being tested in people to make vaginal cuff closure after laparoscopic hysterectomy faster, simpler, and safer.
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A safer, faster, and more affordable way to remove large uteri during minimally invasive surgery
A new surgical device to help surgeons remove large uteri quickly and safely during minimally invasive hysterectomy and similar operations, reducing the chance of spreading hidden cancer.
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Creating tools to predict outcomes for Black women with endometrial cancer after surgery
This study is working to create helpful tools for doctors to better understand and treat Black women with endometrial cancer after surgery, aiming to improve their care and outcomes by considering their unique needs and risks.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.