Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
Official title: Developing and Validating Prognostic Models for Black women with Endometrial Cancer following Hysterectomy
Funded at University of Tx Md Anderson Can Ctr · NIH-11595422 · Data updated 2026-11-12
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 13, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00CA297013-03 |
| Project ID | NIH-11595422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Black women who have undergone hysterectomy for endometrial cancer and are facing post-operative treatment decisions.
✕Less likely to help
Patients not diagnosed with endometrial cancer or not in the post-hysterectomy treatment planning stage may not benefit from this specific prognostic tool.
What this research studies
This grant focuses on Black women who have had a hysterectomy for endometrial cancer and seeks to develop prognostic models using data that are readily available in typical care settings. The researchers will build and externally validate tools to predict recurrence and survival, guiding decisions about additional therapies after surgery. The work aims to balance the benefits and harms of adjuvant treatments so patients receive personalized care. It represents a step toward more equitable, data-driven discussions between patients and clinicians.
Why it matters
Potential benefit: If successful, these tools could help clinicians and patients make better-informed post-surgery treatment choices, potentially improving outcomes for Black women with endometrial cancer.
How similar studies have gone: Previous prognostic models exist for endometrial cancer, but this project emphasizes race-specific validation to improve applicability for Black women.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Peeri, Noah Charles — University of Tx Md Anderson Can Ctr
- Study coordinator: Peeri, Noah Charles
Related research
Other NIH-funded projects on the same topics.
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Creating tools to predict outcomes for Black women with endometrial cancer after surgery
This study is working to create helpful tools for doctors to better understand and treat Black women with endometrial cancer after surgery, aiming to improve their care and outcomes by considering their unique needs and risks.
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Understanding why guideline-concordant endometrial cancer treatment varies in high-risk groups
This project looks at why some patients with endometrial cancer don’t receive care that follows national guidelines, aiming to find ways to ensure more patients get the best-supported treatments.
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Targeting hormone resistance to prevent endometrial cancer
Aims to boost progesterone’s cancer-preventing effect in the lining of the uterus to stop cancer from developing in people at risk, especially those who are obese or young.
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Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
A cancer treatment study is testing whether blocking AXL with batiraxcept together with standard chemotherapy can help people with certain aggressive uterine cancers respond better.
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Targeting HSPA Proteins to Help Women with Advanced or Recurrent Endometrial Cancer
Aims to test a drug called SHetA2 that may slow or stop growth of advanced endometrial cancer by targeting cancer-friendlier proteins, with a focus on reducing treatment toxicity.
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Endometrial Cancer SPORE: New strategies to prevent and treat endometrial cancer
A multi-institution program is testing new ways to prevent and treat endometrial cancer in people, with three linked projects and multiple cores to support translational research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.