Shorter antifungal treatment for kids with candidemia
Official title: Short Course Versus Standard Course Antifungal Therapy for Pediatric Candidemia: A Multi-Center Randomized Controlled Trial
Funded at Arkansas Children's Hospital Res Inst · NIH-11606531 · Data updated 2026-11-12
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $25,000 |
| NIH project number | 3R01AI170385-05S4 |
| Project ID | NIH-11606531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with candidemia who have shown clinical improvement after the first 7 days of echinocandin therapy.
✕Less likely to help
Children who do not respond to initial therapy or have complicated infections may not benefit from a shorter course.
What this research studies
This trial focuses on pediatric patients with invasive candidemia who are improving after 7 days of an echinocandin antifungal. After the initial week, investigators will compare shortening the total 14-day treatment to one with 7 additional days to see if it is still effective and safe. The study uses a randomized design across several centers to provide clear, pediatric-relevant evidence that could change how long children receive antifungal therapy. By targeting a common pediatric fungal infection, the trial aims to reduce drug exposure and potential side effects without compromising outcomes.
Why it matters
Potential benefit: If shorter therapy is as effective, children could receive less antifungal medication and face fewer side effects.
How similar studies have gone: Prior adult studies and pediatric observational data suggest safety with shorter durations for other infections, but this trial tests duration specifically for pediatric candidemia.
Where this research is happening
-
Arkansas Children's Hospital Res Inst
Little Rock, United States Active
Researchers
- Principal investigator: Steinbach, William J — Arkansas Children's Hospital Res Inst
- Study coordinator: Steinbach, William J
Related research
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Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
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Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
-
Shortened antifungal treatment for kids with candidemia
A pediatric multicenter trial will test whether stopping antifungal therapy after 7 more days, following an initial 7 days of treatment, isas safe as continuing for 14 days.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.