Shorter antifungal course for kids with candidemia
Official title: Short Course Versus Standard Course Antifungal Therapy for Pediatric Candidemia: A Multi-Center Randomized Controlled Trial
Funded at Arkansas Children's Hospital Res Inst · NIH-11606502 · Data updated 2026-11-12
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $25,000 |
| NIH project number | 3R01AI170385-05S2 |
| Project ID | NIH-11606502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pediatric patients with invasive candidemia who show clinical improvement after an initial 7 days of echinocandin therapy.
✕Less likely to help
Children who do not improve or have complicated disseminated disease may not benefit from shorter durations.
What this research studies
This trial looks at pediatric patients with bloodstream fungal infections who have begun echinocandin therapy and are improving. After an initial 7 days of treatment, researchers will compare stopping at 7 more days versus continuing for a standard longer duration to see if shorter therapy works just as well. The study design is a randomized controlled trial across multiple centers to provide clear guidance for how long treatment should last. Outcomes will focus on safety, recovery, and relapse to help clinicians personalize care for children. If successful, results could simplify regimens and reduce exposure to antifungal drugs in kids.
Why it matters
Potential benefit: If shorter therapy is as effective, children may experience fewer drug exposures and related side effects.
How similar studies have gone: No prior randomized data in children; adult data and pediatric observational work inform the approach, making this study novel in its specific pediatric duration question.
Where this research is happening
-
Arkansas Children's Hospital Res Inst
Little Rock, United States Active
Researchers
- Principal investigator: Steinbach, William J — Arkansas Children's Hospital Res Inst
- Study coordinator: Steinbach, William J
Related research
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Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
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Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
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Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
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Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
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Shortened antifungal treatment for kids with candidemia
A pediatric multicenter trial will test whether stopping antifungal therapy after 7 more days, following an initial 7 days of treatment, isas safe as continuing for 14 days.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.