Investigating how a specific protein contributes to the progression of breast cancer
Cytoplasmic cyclin E is an early event for progression to invasive breast cancer
This study is looking at a protein called cyclin E and how its changes might lead to aggressive breast cancer, with the hope that understanding these early changes can help improve early detection and treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10550153 on NIH RePORTER |
What this research studies
This research focuses on cyclin E, a protein that plays a crucial role in cell division, and its modified forms that are linked to breast cancer. By using advanced models, the team aims to understand how early changes in the mammary gland can lead to aggressive tumors. The study examines the genetic alterations and cellular processes that occur when cyclin E is present, potentially leading to invasive breast cancer. Patients may benefit from insights into early detection and targeted therapies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for breast cancer, particularly those with a family history or genetic predispositions.
Not a fit: Patients with advanced or metastatic breast cancer may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of cyclin E in cancer progression, indicating that this approach has potential for significant findings.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Keyomarsi, Khandan — University of Tx Md Anderson Can Ctr
- Study coordinator: Keyomarsi, Khandan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.