Investigating how a specific protein contributes to the progression of breast cancer
Official title: Cytoplasmic cyclin E is an early event for progression to invasive breast cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-10550153 · Data updated 2026-11-12
This study is looking at a protein called cyclin E and how its changes might lead to aggressive breast cancer, with the hope that understanding these early changes can help improve early detection and treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 1, 2018 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $386,160 |
| NIH project number | 5R01CA223772-06 |
| Project ID | NIH-10550153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for breast cancer, particularly those with a family history or genetic predispositions.
✕Less likely to help
Patients with advanced or metastatic breast cancer may not benefit directly from this research.
What this research studies
This research focuses on cyclin E, a protein that plays a crucial role in cell division, and its modified forms that are linked to breast cancer. By using advanced models, the team aims to understand how early changes in the mammary gland can lead to aggressive tumors. The study examines the genetic alterations and cellular processes that occur when cyclin E is present, potentially leading to invasive breast cancer. Patients may benefit from insights into early detection and targeted therapies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for breast cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of cyclin E in cancer progression, indicating that this approach has potential for significant findings.
Where this research is happening
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University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Keyomarsi, Khandan — University of Tx Md Anderson Can Ctr
- Study coordinator: Keyomarsi, Khandan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.